Document Detail

Postconception menses induction using prostaglandin vaginal suppositories.
MedLine Citation:
PMID:  3982746     Owner:  NLM     Status:  MEDLINE    
Vaginal suppositories containing 15 methyl prostaglandin F2 alpha methyl ester in a high-melt base were administered to 60 women desiring early pregnancy interruption who were no more than 56 days' (eight weeks) pregnant as calculated from the first day of the last regular menstrual period (LMP). The purpose of this study was to evaluate the safety, efficacy, and patient acceptability of this mode of noninvasive early abortion. Some factors evaluated during the study included the time interval from insertion of the suppository to the onset of cramping and bleeding. Also measured were immediate and delayed blood loss, nausea, vomiting, and diarrhea. Of the 60 patients entered into the study, 55 procedures have been judged as successful by the prospective criteria set forth in the protocol. There were no deaths or serious complications. Four patients required hospitalization and follow-up dilatation and curettage (D&C). One patient withdrew from the study after receiving a suppository and subsequently delivered a preterm infant.
H W Foster; M Smith; C E McGruder; F Richard; J McIntyre
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  65     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1985 May 
Date Detail:
Created Date:  1985-05-23     Completed Date:  1985-05-23     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  682-5     Citation Subset:  AIM; IM    
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MeSH Terms
Abortion, Induced / methods*
Diarrhea / chemically induced
Menstruation / drug effects
Nausea / chemically induced
Pregnancy Trimester, First
Prostaglandins / adverse effects,  pharmacology*
Uterine Contraction / drug effects
Vomiting / chemically induced
Reg. No./Substance:
0/Prostaglandins; 0/Suppositories

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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