Document Detail

Postchallenge hyperglycaemic spike associate with arterial stiffness.
MedLine Citation:
PMID:  17313605     Owner:  NLM     Status:  MEDLINE    
Several large-scale epidemiological and intervention studies strongly indicate that postchallenge hyperglycaemia is the main factor associated with increasing the risk of morbidity and mortality in type 2 diabetes. However, the mechanisms that increase the risk of cardiovascular disease remain unclear. We aimed to study the relationship between postchallenge hyperglycaemia and arterial stiffness. We recruited 40 healthy subjects from a physical examination in 2005. Cardio-ankle vascular index (CAVI) was automatically calculated by VaSera VS-1000. For the reliability study, we performed the baseline study in the first 20 subjects who were returned to receive repeated measurements of CAVI 2 weeks later. The determinants of mean CAVI at different timings of oral glucose tolerance test (OGTT) study were analysed by constructing multivariate linear regression models. In reliability test, the inter-observer correlation coefficient was 0.82 for right CAVI, 0.87 for left CAVI and 0.85 for mean CAVI. Age, systolic blood pressure (SBP), diastolic blood pressure (DBP), glucose levels at 60 min (Glu60) and glucose area under the curve of OGTT (GluAUC) are found to be significantly and positively correlated to right CAVI, left CAVI and mean CAVI (p < 0.05). After adjustment for age, gender and SBP, Glu60 and GluAUC are still independent determinants of CAVI. In subjects without clinical diagnosis of type 2 diabetes, postchallenge hyperglycaemic spike is highly associated with CAVI, a good parameter of aortic stiffness, independent of age, gender and blood pressure.
C-L Huang; M-F Chen; J-S Jeng; L-Y Lin; W-L Wang; M-H Feng; C-S Liau; B-S Hwang; Y-T Lee; T-C Su
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of clinical practice     Volume:  61     ISSN:  1368-5031     ISO Abbreviation:  Int. J. Clin. Pract.     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-02-22     Completed Date:  2007-12-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9712381     Medline TA:  Int J Clin Pract     Country:  England    
Other Details:
Languages:  eng     Pagination:  397-402     Citation Subset:  IM    
Department of Internal Medicine, University Hospital, National Taiwan University College of Medicine, #7 Chung-Shan South Road, Taipei 100, Taiwan.
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MeSH Terms
Arteries / physiopathology
Blood Glucose / metabolism
Blood Pressure / physiology
Diabetes Mellitus, Type 2 / etiology*,  physiopathology
Diabetic Angiopathies / etiology*,  physiopathology
Glucose Tolerance Test*
Hyperglycemia / etiology*,  physiopathology
Middle Aged
Regression Analysis
Reproducibility of Results
Risk Factors
Vascular Resistance / physiology
Reg. No./Substance:
0/Blood Glucose
Comment In:
Int J Clin Pract. 2007 Mar;61(3):356-8   [PMID:  17313598 ]

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