| Postchallenge hyperglycaemic spike associate with arterial stiffness. | |
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MedLine Citation:
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PMID: 17313605 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Several large-scale epidemiological and intervention studies strongly indicate that postchallenge hyperglycaemia is the main factor associated with increasing the risk of morbidity and mortality in type 2 diabetes. However, the mechanisms that increase the risk of cardiovascular disease remain unclear. We aimed to study the relationship between postchallenge hyperglycaemia and arterial stiffness. We recruited 40 healthy subjects from a physical examination in 2005. Cardio-ankle vascular index (CAVI) was automatically calculated by VaSera VS-1000. For the reliability study, we performed the baseline study in the first 20 subjects who were returned to receive repeated measurements of CAVI 2 weeks later. The determinants of mean CAVI at different timings of oral glucose tolerance test (OGTT) study were analysed by constructing multivariate linear regression models. In reliability test, the inter-observer correlation coefficient was 0.82 for right CAVI, 0.87 for left CAVI and 0.85 for mean CAVI. Age, systolic blood pressure (SBP), diastolic blood pressure (DBP), glucose levels at 60 min (Glu60) and glucose area under the curve of OGTT (GluAUC) are found to be significantly and positively correlated to right CAVI, left CAVI and mean CAVI (p < 0.05). After adjustment for age, gender and SBP, Glu60 and GluAUC are still independent determinants of CAVI. In subjects without clinical diagnosis of type 2 diabetes, postchallenge hyperglycaemic spike is highly associated with CAVI, a good parameter of aortic stiffness, independent of age, gender and blood pressure. |
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Authors:
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C-L Huang; M-F Chen; J-S Jeng; L-Y Lin; W-L Wang; M-H Feng; C-S Liau; B-S Hwang; Y-T Lee; T-C Su |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of clinical practice Volume: 61 ISSN: 1368-5031 ISO Abbreviation: Int. J. Clin. Pract. Publication Date: 2007 Mar |
Date Detail:
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Created Date: 2007-02-22 Completed Date: 2007-12-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9712381 Medline TA: Int J Clin Pract Country: England |
Other Details:
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Languages: eng Pagination: 397-402 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, University Hospital, National Taiwan University College of Medicine, #7 Chung-Shan South Road, Taipei 100, Taiwan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Arteries / physiopathology Blood Glucose / metabolism Blood Pressure / physiology Compliance Diabetes Mellitus, Type 2 / etiology*, physiopathology Diabetic Angiopathies / etiology*, physiopathology Female Glucose Tolerance Test* Humans Hyperglycemia / etiology*, physiopathology Male Middle Aged Regression Analysis Reproducibility of Results Risk Factors Vascular Resistance / physiology |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose |
| Comments/Corrections | |
Comment In:
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Int J Clin Pract. 2007 Mar;61(3):356-8
[PMID:
17313598
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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