Document Detail


Postburn galactorrhea with refractory hypertrophic scars: role of obesity under scrutiny.
MedLine Citation:
PMID:  14610425     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Postburn galactorrhea, although relatively uncommon, is a complex problem to treat. Three of 25 female premenopausal patients who were admitted during the years 1995 to 2001 with more than 40% TBSA burns developed this problem. All three patients were obese according to body mass index and other clinical criteria. It was observed that the additional disturbance of equilibrium of hypothalamus because of burn injury, which is already disturbed as per se in obese patients, precipitates sustained release of prolactin, leading to galactorrhea. Hyperinsulinemia because of obesity and associated reactive metabolic response of burn trauma contribute to the stimulation of prolactin secretion and sustained hyperprolactinemia. Interestingly, our patients who developed postburn galactorrhea also developed refractory hypertrophic scars not readily amenable to preventive and conservative therapeutic treatment methods. The responsible factor for its development can be a rise in prolactin levels with interplay of other hormones, such as melanocyte-stimulating hormone (MSH), from the anterior pituitary. Repeated serum prolactin measurements and early control of rising levels during the burn treatment, particularly in obese patients, are recommended. Early and vigorous measures to prevent scar hypertrophy also are advocated. In our study, we failed to correlate chest wall burns with galactorrhea.
Authors:
Hemant Saraiya
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Journal of burn care & rehabilitation     Volume:  24     ISSN:  0273-8481     ISO Abbreviation:  J Burn Care Rehabil     Publication Date:    2003 Nov-Dec
Date Detail:
Created Date:  2003-11-11     Completed Date:  2004-03-16     Revised Date:  2006-08-15    
Medline Journal Info:
Nlm Unique ID:  8110188     Medline TA:  J Burn Care Rehabil     Country:  United States    
Other Details:
Languages:  eng     Pagination:  392-4     Citation Subset:  IM    
Affiliation:
Sushrut Plastic Surgery Research Center and Faiz-E-Quthi Charitable Trust Hospital, Ahmedabad, India.
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MeSH Terms
Descriptor/Qualifier:
Adult
Burns / complications*
Cicatrix, Hypertrophic / complications*
Female
Galactorrhea / etiology*
Humans
Obesity / complications*
Prolactin / blood,  pharmacology
Chemical
Reg. No./Substance:
9002-62-4/Prolactin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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