| Postburn galactorrhea with refractory hypertrophic scars: role of obesity under scrutiny. | |
MedLine Citation:
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PMID: 14610425 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Postburn galactorrhea, although relatively uncommon, is a complex problem to treat. Three of 25 female premenopausal patients who were admitted during the years 1995 to 2001 with more than 40% TBSA burns developed this problem. All three patients were obese according to body mass index and other clinical criteria. It was observed that the additional disturbance of equilibrium of hypothalamus because of burn injury, which is already disturbed as per se in obese patients, precipitates sustained release of prolactin, leading to galactorrhea. Hyperinsulinemia because of obesity and associated reactive metabolic response of burn trauma contribute to the stimulation of prolactin secretion and sustained hyperprolactinemia. Interestingly, our patients who developed postburn galactorrhea also developed refractory hypertrophic scars not readily amenable to preventive and conservative therapeutic treatment methods. The responsible factor for its development can be a rise in prolactin levels with interplay of other hormones, such as melanocyte-stimulating hormone (MSH), from the anterior pituitary. Repeated serum prolactin measurements and early control of rising levels during the burn treatment, particularly in obese patients, are recommended. Early and vigorous measures to prevent scar hypertrophy also are advocated. In our study, we failed to correlate chest wall burns with galactorrhea. |
Authors:
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Hemant Saraiya |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The Journal of burn care & rehabilitation Volume: 24 ISSN: 0273-8481 ISO Abbreviation: J Burn Care Rehabil Publication Date: 2003 Nov-Dec |
Date Detail:
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Created Date: 2003-11-11 Completed Date: 2004-03-16 Revised Date: 2006-08-15 |
Medline Journal Info:
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Nlm Unique ID: 8110188 Medline TA: J Burn Care Rehabil Country: United States |
Other Details:
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Languages: eng Pagination: 392-4 Citation Subset: IM |
Affiliation:
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Sushrut Plastic Surgery Research Center and Faiz-E-Quthi Charitable Trust Hospital, Ahmedabad, India. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Burns / complications* Cicatrix, Hypertrophic / complications* Female Galactorrhea / etiology* Humans Obesity / complications* Prolactin / blood, pharmacology |
| Chemical | |
Reg. No./Substance:
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9002-62-4/Prolactin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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