| Postasphyxial encephalopathy in preterm neonates. | |
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MedLine Citation:
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PMID: 11838565 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Perinatal asphyxia is an important determinant of infant neurological outcome. There are very few studies looking exclusively at postasphyxial encephalopathy in preterm neonates. METHODS: We studied the neurologic and sonographic abnormalities in 40 preterm babies with severe birth asphyxia during their hospital stay and till 3 months corrected age. RESULT: 87.5 % of the asphyxiated preterm babies had neonatal neurologic abnormality, compared to only 17% of the control babies (p<0.0001). Generalised hypotonia and reduced activity were the commonest abnormalities (observed in 85% of asphyxiated babies) while depressed sensorium (60%) and seizures (35%) were seen in more severe cases. White matter disease (WMD-including periventricular flare, cerebral edema and periventricular leucomalacia) was significantly more frequent in the study cases (34.5% in study cases vs 7.5% in controls, p<0.0001) as was grade 3/4 intraventricular hemorrhage(IVH) (25% in study cases vs 2.5% in controls, p<0.0001). There was 11 fold higher mortality among the asphyxiated babies (23 deaths in study cases vs 2 in controls, p<0.0001). CONCLUSION: The survivors had a significantly higher incidence of both mild and severe neurological abnormalities at corrected age of 3 months among the asphyxiated babies. There was a good correlation between the severity of the neonatal encephalopathy as well as the sonographic findings and the outcome. |
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Authors:
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K Sridhar; P Kumar; S Katariya; A Narang |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Indian journal of pediatrics Volume: 68 ISSN: 0019-5456 ISO Abbreviation: Indian J Pediatr Publication Date: 2001 Dec |
Date Detail:
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Created Date: 2002-02-12 Completed Date: 2002-03-05 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0417442 Medline TA: Indian J Pediatr Country: India |
Other Details:
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Languages: eng Pagination: 1121-5 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, PGIMER, Chandigarh, India. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Asphyxia Neonatorum
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complications*,
mortality Case-Control Studies Female Follow-Up Studies Humans India / epidemiology Infant Infant, Newborn Infant, Premature* Male Nervous System Diseases / epidemiology, etiology*, ultrasonography |
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