| Post-weaning voluntary exercise exerts long-term moderation of adiposity in males but not in females in an animal model of early-onset obesity. | |
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MedLine Citation:
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PMID: 20193686 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Given the alarming increase in childhood, adolescent and adult obesity there is an imperative need for understanding the early factors affecting obesity and for treatments that may help prevent or at least moderate it. Exercise is frequently considered as an effective treatment for obesity however the empirical literature includes many conflicting findings. In the present study, we used the OLETF rat model of early-onset hyperphagia-induced obesity to examine the influence of early exercise on peripheral adiposity-related parameters in both males and females. Rats were provided voluntary access to running wheels from postnatal day (PND) 22 until PND45. We examined fat pad weight (brown, retroperitoneal, inguinal and epididymal); inguinal adipocyte size and number; and leptin, adiponectin, corticosterone and creatinine levels. We also examined body weight, feeding efficiency and spontaneous intake. Early voluntary exercise reduced intake, adiposity and leptin in the OLETF males following a sharp reduction in adipocyte size despite a significant increase in fat cell number. Exercising males from the lean LETO control strain presented stable intake, but reduced body fat, feeding efficiency and increased plasma creatinine, suggesting an increment in muscle mass. OLETF females showed reduced feeding efficiency and liver fat, and a significant increase in brown fat. Exercising LETO control females increased intake, body weight and creatinine, but no changes in body fat. Overall, OLETF rats presented higher adiponectin levels than controls in both basal and post-exercise conditions. The results suggest an effective early time frame, when OLETF males can be successfully "re-programmed" through voluntary exercise; in OLETF females the effect is much more moderate. Findings expose sex-dependent peripheral mechanisms in coping with energy challenges. |
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Authors:
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Mariana Schroeder; Liat Shbiro; Vered Gelber; Aron Weller |
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Publication Detail:
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Type: Journal Article Date: 2010-02-26 |
Journal Detail:
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Title: Hormones and behavior Volume: 57 ISSN: 1095-6867 ISO Abbreviation: Horm Behav Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-05 Completed Date: 2010-07-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0217764 Medline TA: Horm Behav Country: United States |
Other Details:
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Languages: eng Pagination: 496-505 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Life Sciences Faculty, Bar Ilan University, Ramat Gan 52900, Israel. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adiponectin
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blood Adipose Tissue / pathology Adiposity / physiology* Animals Body Weight / physiology Corticosterone / blood Creatinine / blood Eating / physiology Estrous Cycle / physiology Female Hyperphagia / genetics, psychology Leptin / blood Male Motor Activity / physiology Obesity / genetics*, pathology, prevention & control* Physical Conditioning, Animal / physiology* Rats Rats, Inbred OLETF Sex Characteristics |
| Chemical | |
Reg. No./Substance:
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0/Adiponectin; 0/Leptin; 50-22-6/Corticosterone; 60-27-5/Creatinine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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