| Post-weaning handling attenuates isolation-rearing induced disruptions of prepulse inhibition in rats. | |
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MedLine Citation:
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PMID: 11182170 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Isolation rearing is a developmentally specific non-pharmacological manipulation in rats that produces a deficit in sensorimotor gating, as measured by prepulse inhibition (PPI) of the startle reflex. Previous research has demonstrated that the isolation rearing effect on PPI is sensitive to several factors, including the time of testing with respect to length of isolation, prepulse intensities used, strain of rats, and type of housing environment. This study tested whether handling is another factor that interacts with the isolation-rearing paradigm in PPI. Rats were housed either in the social (three rats per cage) or isolate (one rat per cage) conditions and were handled either 1-2 times per week (minimal handling) or on a daily basis (daily handling). All rats were then tested at 8 and 10 weeks post-weaning. There was an interaction between housing and handling. In the minimal handling condition, isolation rearing produced a deficit in PPI. This effect was absent, however, in the daily handling condition. Thus, regular handling of rats may interfere with the observation of the isolation rearing effect on PPI and should be carefully controlled in studies using this animal model of PPI deficits. |
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Authors:
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K Krebs-Thomson; D Giracello; A Solis; M A Geyer |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Behavioural brain research Volume: 120 ISSN: 0166-4328 ISO Abbreviation: Behav. Brain Res. Publication Date: 2001 May |
Date Detail:
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Created Date: 2001-02-22 Completed Date: 2001-06-28 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8004872 Medline TA: Behav Brain Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 221-4 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, University of California-San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0804, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Handling (Psychology)* Male Rats Rats, Sprague-Dawley Social Isolation / psychology* Startle Reaction / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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R01 MH52885/MH/NIMH NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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