Document Detail


Post-transplant diabetes mellitus - Risk factors and effects on the function and morphology of the allograft.
MedLine Citation:
PMID:  22849845     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The incidence of post-transplant diabetes mellitus and its effects on the kidney allograft function and morphology were assessed. Patients were divided into three groups according to their glucose metabolism. Risk factors for diabetes were first assessed, and then changes in renal function were checked. Morphological changes in the allografts were examined by protocol biopsies. The overall incidence of diabetes was 16%. The development of diabetes was influenced significantly by the body mass index, the body weight and the age of the recipient. The incidence of diabetes was 8.6% in patients on cyclosporine A therapy and 28.8% in those on tacrolimus (p < 0.05). As to the morphology of the kidney, a significantly higher proportion of the biopsies showed severe interstitial fibrosis/tubular atrophy (p = 0.0004) and subclinical acute rejection ( p = 0.001) in the diabetic group compared to the normal one. This clinical study has revealed that the adverse effect of diabetes on the allograft can be detected with protocol biopsy before the manifestation of a functional deterioration.
Authors:
Bernadett Borda; Cs Lengyel; E Szederkényi; J Eller; Cs Keresztes; G Lázár
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta physiologica Hungarica     Volume:  99     ISSN:  0231-424X     ISO Abbreviation:  Acta Physiol Hung     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-08-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8309201     Medline TA:  Acta Physiol Hung     Country:  Hungary    
Other Details:
Languages:  eng     Pagination:  206-15     Citation Subset:  IM    
Affiliation:
University of Szeged Department of Surgery, Faculty of Medicine Szeged Hungary University of Szeged Department of Surgery, Faculty of Medicine Pécsi u. 6 H-6720 Szeged Hungary.
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