| Post-translational regulation of activation-induced cytidine deaminase. | |
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MedLine Citation:
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PMID: 19010772 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The assembled immunoglobulin genes in the B cells of mice and humans are altered by distinct processes known as class switch recombination (CSR) and somatic hypermutation, leading to diversification of the antibody repertoire. These two DNA modification processes are initiated by the B cell-specific protein factor activation-induced cytidine deaminase (AID). AID is post-translationally modified by phosphorylation at multiple sites, although functional significance during CSR has been implicated only for phosphorylation at serine-38 (S38). Although multiple laboratories have demonstrated that AID function is regulated via phosphorylation at S38, the precise biological role of S38 phosphorylation has been a topic of debate. Here, we discuss our interpretation of the significance of AID regulation via phosphorylation and also discuss how this form of AID regulation may have evolved in higher organisms. |
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Authors:
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Uttiya Basu; Andrew Franklin; Frederick W Alt |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Philosophical transactions of the Royal Society of London. Series B, Biological sciences Volume: 364 ISSN: 1471-2970 ISO Abbreviation: Philos. Trans. R. Soc. Lond., B, Biol. Sci. Publication Date: 2009 Mar |
Date Detail:
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Created Date: 2009-01-29 Completed Date: 2009-03-27 Revised Date: 2010-09-22 |
Medline Journal Info:
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Nlm Unique ID: 7503623 Medline TA: Philos Trans R Soc Lond B Biol Sci Country: England |
Other Details:
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Languages: eng Pagination: 667-73 Citation Subset: IM |
Affiliation:
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Howard Hughes Medical Institute, The Children's Hospital, Boston, MA 02115, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Animals Cytidine Deaminase / genetics, metabolism* Enzyme Activation Evolution* Immunoglobulin Class Switching / genetics* Models, Biological Molecular Sequence Data Phosphorylation Somatic Hypermutation, Immunoglobulin / genetics* Zebrafish |
| Chemical | |
Reg. No./Substance:
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EC 3.5.4.5/Cytidine Deaminase |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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