| Post-translational regulation of L-glutamic acid decarboxylase in the brain. | |
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MedLine Citation:
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PMID: 18270816 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. GABA is converted from glutamic acid by the action of glutamic acid decarboxylase (GAD). There are two forms of GAD in the brain, GAD65 and GAD67, referring to a molecular weight of 65 and 67 kDa, respectively. Perturbations in GABAergic neurotransmission have been linked to a number of neurological disorders. Since GAD is the rate-limiting enzyme in controlling GABA synthesis, it is important to understand how GAD is regulated in the brain. It is known that GAD function can be regulated at the transcriptional/translational and post-translational levels. This review focuses briefly on the recent advances in revealing the post-translational regulation of GAD function including protein phosphorylation, palmitoylation and activity-dependent cleavage. The results from these studies have improved our understanding of the regulation of GAD function in the brain. |
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Authors:
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Jianning Wei; Jang-Yen Wu |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2008-02-13 |
Journal Detail:
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Title: Neurochemical research Volume: 33 ISSN: 1573-6903 ISO Abbreviation: Neurochem. Res. Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-06-30 Completed Date: 2008-11-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7613461 Medline TA: Neurochem Res Country: United States |
Other Details:
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Languages: eng Pagination: 1459-65 Citation Subset: IM |
Affiliation:
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Department of Basic Science, Charles E. Schmidt College of Biomedical Science, Florida Atlantic University, Boca Raton, FL 33431, USA. jwei@fau.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Animals Brain / enzymology* Glutamate Decarboxylase / genetics, metabolism* Humans Isoenzymes / genetics, metabolism* Molecular Sequence Data Protein Processing, Post-Translational* Sequence Alignment gamma-Aminobutyric Acid / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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NS37851/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Isoenzymes; 56-12-2/gamma-Aminobutyric Acid; EC 4.1.1.15/Glutamate Decarboxylase |
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