| Post-transfusional variation in urinary oxygen tension in surgical patients. | |
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MedLine Citation:
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PMID: 18430049 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Prior studies have suggested urinary oxygen tension (P(u)O2) as a putative index of renal blood flow (RBF) and tissue oxygenation. In the present study, we collected intraoperative data from eight anaemic, bladder-catheterized patients who received erythrocyte transfusions during various surgical procedures under general anaesthesia. Urinary and arterial blood gas analysis and co-oximetry were performed before and after transfusion, during an interval in which RBF was assumed to be constant. Pre- and post-transfusion haematocrit levels were 23 +/- 4.8 and 27 +/- 6.4%, respectively, and arterial oxygen content (C(a)O2) was 10.5 +/- 2.5 and 12.4 +/- 3.1 mL/dL, respectively (P = 0.012). Pre- and post-transfusion P(u)O2 was 90 +/- 14 and 108 +/- 20 mmHg, respectively (P = 0.036). 4. These results, although limited, suggest that under conditions of stable haemodynamics, systemic oxygenation and renal function, intraoperative blood transfusion may increase P(u)O2 in anaemic anaesthetized patients. If confirmed by subsequent clinical and laboratory studies, P(u)O2 measurement could become a simple, non-invasive way to monitor renal medullary oxygenation and tissue oxygen availability and help determine whether red blood cells should be transfused. |
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Authors:
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Alessio Valente; Luca Sorrentino; Giuseppe La Torre; Gaetano Draisci |
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Publication Detail:
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Type: Clinical Trial; Journal Article Date: 2008-04-21 |
Journal Detail:
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Title: Clinical and experimental pharmacology & physiology Volume: 35 ISSN: 1440-1681 ISO Abbreviation: Clin. Exp. Pharmacol. Physiol. Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-09-10 Completed Date: 2009-01-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0425076 Medline TA: Clin Exp Pharmacol Physiol Country: Australia |
Other Details:
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Languages: eng Pagination: 1109-12 Citation Subset: IM |
Affiliation:
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Department of Emergency Medicine, Institute of Anesthesiology and Resuscitation Medicine, Rome, Italy. neurobios@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Arteries / chemistry Blood Gas Analysis Blood Pressure Erythrocyte Transfusion* Female Heart Rate / physiology Hematocrit Hemoglobins / analysis Humans Male Middle Aged Oxygen / blood, urine* Pilot Projects Postoperative Hemorrhage / blood, therapy*, urine |
| Chemical | |
Reg. No./Substance:
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0/Hemoglobins; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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