Document Detail

Post-transcriptional processing of genetic information and its relation to cancer.
MedLine Citation:
PMID:  23286224     Owner:  NLM     Status:  MEDLINE    
During the development, progression and dissemination of neoplastic lesions, cancer cells hijack normal pathways and mechanisms, especially those involved in repair and embryologic development. These pathways include those involved in intercellular communication, control of transcription, post-transcriptional regulation of protein production including translation of mRNAs, post-translational protein modifications, e.g., acetylation of proteins, and protein degradation. Small, non-translatable RNAs, especially microRNAs (miRs), are Important components of post-transcriptional control. MiRs are produced from areas of the genome that are not translated into proteins, but may be co-regulated with their associated genes. MiRs bind to the 3' untranslated regions of mRNAs and regulate the expression of genes in most cases by either promoting the degradation of mRNA and/or inhibiting the translation of mRNAs into proteins; thus, miRs usually cause a decrease in protein levels that would be expected if the mRNAs were translated normally. It is early in our understanding of how miRs affect neoplastic processes, but miRs are expressed differentially in most cancers and have been associated with tumor progression, chemoresistance and metastasis. MiRs are present in nanovesicles, such as exosomes, and thus are likely involved in intercellular communication, especially in neoplasia. MiRs are attractive targets for novel therapies of cancer as well as potential biomarkers that might be useful for early detection and diagnosis, and for prediction of therapeutic efficacy. MiRs also could aid and in determining prognosis, evaluating novel therapies, and developing preventive strategies by their use as surrogate end points.
Lr McNally; U Manne; W E Grizzle
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2013-01-04
Journal Detail:
Title:  Biotechnic & histochemistry : official publication of the Biological Stain Commission     Volume:  88     ISSN:  1473-7760     ISO Abbreviation:  Biotech Histochem     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-09-17     Completed Date:  2014-04-08     Revised Date:  2014-11-13    
Medline Journal Info:
Nlm Unique ID:  9107378     Medline TA:  Biotech Histochem     Country:  England    
Other Details:
Languages:  eng     Pagination:  365-72     Citation Subset:  IM    
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MeSH Terms
Gene Expression Regulation, Neoplastic / physiology*
Neoplasms / genetics,  metabolism*
RNA / classification,  genetics,  metabolism
RNA Processing, Post-Transcriptional / physiology*
Grant Support
(2U54CA118948/CA/NCI NIH HHS; 2P50CA101955/CA/NCI NIH HHS; 5P50CA089019/CA/NCI NIH HHS; 5P50CA098252/CA/NCI NIH HHS; K99 CA139050/CA/NCI NIH HHS; K99 R00 CA139050-03/CA/NCI NIH HHS; P20 CA101955/CA/NCI NIH HHS; P30 AR050948/AR/NIAMS NIH HHS; P30AR50948/AR/NIAMS NIH HHS; P50 CA089019/CA/NCI NIH HHS; P50 CA098252/CA/NCI NIH HHS; U54 CA118948/CA/NCI NIH HHS
Reg. No./Substance:

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