Document Detail

Post-thyroidectomy hypocalcaemia: A feature of the operation or the thyroid disorder?
MedLine Citation:
PMID:  66427     Owner:  NLM     Status:  MEDLINE    
It has been suggested that post-thyroidectomy hypocalcaemia is related to the presence of a thyrotoxic osteodystrophy for which a high serum concentration of bone alkaline phosphatase is a marker. Changes in serum-calcium (corrected to a standard albumin concentration of 40 g/l), alkaline phosphatase (A.P.), inorganic phosphate, and albumin were studied prospectively in 54 euthyroid patients with drug-treated Graves' disease, and in 17 controls with simple non-toxic goitre, before and serially after partial thyroidectomy. All data were paired and results indicate that the pattern of biochemical change was the same in both types of patient and that the degree of change was not related to the serum-A.P. concentration in the Graves'-disease patients. Of the patients studied within the first 24 h of operation, 5 out of 12 with Graves' disease and raised serum-A.P. (group I), 9 of 20 with Graves' disease and normal serum-A.P. (group II), and 7 of 15 controls (group III) showed a fall in serum-calcium below the lower limit of the reference range. In all three groups there was a highly significant fall in serum-calcium 24 h after operation but there was no significant difference in serum-calcium between the groups either immediately before or 24 h after operation. Serum-calcium returned to pre-surgical concentrations within 7 days of thyroidectomy and serum-A.P. concentrations by 4 to 6 weeks in all groups. There was no evidence that post-thyroidectomy hypocalcaemia is related to thyrotoxic osteodystrophy and the pattern of the biochemical changes was thought to be consistent with release of thyrocalcitonin at operation.
T J Wilkin; T E Isles; C R Paterson; J Crooks; J Beck
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Lancet     Volume:  1     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1977 Mar 
Date Detail:
Created Date:  1977-05-12     Completed Date:  1977-05-12     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  621-3     Citation Subset:  AIM; IM    
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MeSH Terms
Alkaline Phosphatase / blood
Bone and Bones / metabolism
Calcitonin / secretion
Calcium / blood
Goiter / metabolism,  surgery
Graves Disease / metabolism,  surgery
Hypocalcemia / etiology*
Middle Aged
Phosphates / blood
Prospective Studies
Serum Albumin / blood
Thyroidectomy / adverse effects*
Time Factors
Reg. No./Substance:
0/Phosphates; 0/Serum Albumin; 7440-70-2/Calcium; 9007-12-9/Calcitonin; EC Phosphatase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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