| Post-tetanic count and train-of-four responses during neuromuscular block produced by vecuronium and infusion of nicardipine. | |
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MedLine Citation:
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PMID: 10618956 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have examined onset and recovery of neuromuscular block produced by vecuronium using either post-tetanic count (PTC), or the first twitch of the train-of-four (TOF) (T1/T0) and TOF ratio (T4/T1) during continuous infusion of nicardipine. Sixty adult patients were allocated to one of four groups of 15 patients each: nicardipine-PTC, nicardipine-TOF, control-PTC and control-TOF. In the nicardipine-PTC and nicardipine-TOF groups, nicardipine 0.03 mg kg-1 was given before vecuronium 0.1 mg kg-1 and a continuous infusion of nicardipine was started immediately at a rate of 2 micrograms kg-1 min-1. Mean time from administration of vecuronium to onset of neuromuscular block in the nicardipine-PTC and nicardipine-TOF groups was significantly shorter than in the control-PTC and control-TOF groups (166 (SD 39) vs 220 (28) s; P < 0.05). There was no significant difference in recovery of PTC between the nicardipine-PTC and control-PTC groups or in recovery of TOF ratio in the nicardipine-TOF and control-TOF groups. However, during recovery, T1/T0 in the nicardipine-TOF group was significantly less than that in the control-TOF group, 60-100 min after administration of vecuronium. |
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Authors:
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Y Saitoh; Y Narumi; Y Fujii |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Retracted Publication |
Journal Detail:
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Title: British journal of anaesthesia Volume: 83 ISSN: 0007-0912 ISO Abbreviation: Br J Anaesth Publication Date: 1999 Aug |
Date Detail:
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Created Date: 2000-01-06 Completed Date: 2000-01-06 Revised Date: 2013-04-26 |
Medline Journal Info:
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Nlm Unique ID: 0372541 Medline TA: Br J Anaesth Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 340-2 Citation Subset: IM |
Affiliation:
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Department of Anaesthesiology, Toride Kyodo General Hospital, Ibaraki, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Analysis of Variance Anesthesia Recovery Period* Calcium Channel Blockers / administration & dosage* Electric Stimulation Humans Infusions, Intravenous Neuromuscular Blockade* Neuromuscular Nondepolarizing Agents* Nicardipine / administration & dosage* Vecuronium Bromide* |
| Chemical | |
Reg. No./Substance:
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0/Calcium Channel Blockers; 0/Neuromuscular Nondepolarizing Agents; 50700-72-6/Vecuronium Bromide; 55985-32-5/Nicardipine |
| Comments/Corrections | |
Retraction In:
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Br J Anaesth. 2013 Apr;110(4):669
[PMID:
23508503
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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