Document Detail

Post-tetanic count and train-of-four responses during neuromuscular block produced by vecuronium and infusion of nicardipine.
MedLine Citation:
PMID:  10618956     Owner:  NLM     Status:  MEDLINE    
We have examined onset and recovery of neuromuscular block produced by vecuronium using either post-tetanic count (PTC), or the first twitch of the train-of-four (TOF) (T1/T0) and TOF ratio (T4/T1) during continuous infusion of nicardipine. Sixty adult patients were allocated to one of four groups of 15 patients each: nicardipine-PTC, nicardipine-TOF, control-PTC and control-TOF. In the nicardipine-PTC and nicardipine-TOF groups, nicardipine 0.03 mg kg-1 was given before vecuronium 0.1 mg kg-1 and a continuous infusion of nicardipine was started immediately at a rate of 2 micrograms kg-1 min-1. Mean time from administration of vecuronium to onset of neuromuscular block in the nicardipine-PTC and nicardipine-TOF groups was significantly shorter than in the control-PTC and control-TOF groups (166 (SD 39) vs 220 (28) s; P < 0.05). There was no significant difference in recovery of PTC between the nicardipine-PTC and control-PTC groups or in recovery of TOF ratio in the nicardipine-TOF and control-TOF groups. However, during recovery, T1/T0 in the nicardipine-TOF group was significantly less than that in the control-TOF group, 60-100 min after administration of vecuronium.
Y Saitoh; Y Narumi; Y Fujii
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Retracted Publication    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  83     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  1999 Aug 
Date Detail:
Created Date:  2000-01-06     Completed Date:  2000-01-06     Revised Date:  2013-04-26    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  340-2     Citation Subset:  IM    
Department of Anaesthesiology, Toride Kyodo General Hospital, Ibaraki, Japan.
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MeSH Terms
Analysis of Variance
Anesthesia Recovery Period*
Calcium Channel Blockers / administration & dosage*
Electric Stimulation
Infusions, Intravenous
Neuromuscular Blockade*
Neuromuscular Nondepolarizing Agents*
Nicardipine / administration & dosage*
Vecuronium Bromide*
Reg. No./Substance:
0/Calcium Channel Blockers; 0/Neuromuscular Nondepolarizing Agents; 50700-72-6/Vecuronium Bromide; 55985-32-5/Nicardipine
Retraction In:
Br J Anaesth. 2013 Apr;110(4):669   [PMID:  23508503 ]

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