Document Detail

Post-surgical role of botulinum toxin-A injection in patients with head and neck cancer: personal experience.
MedLine Citation:
PMID:  18533549     Owner:  NLM     Status:  MEDLINE    
Personal experience is discussed in the use of botulinum neurotoxin injections into both parotids, performed in order to transiently reduce salivation in patients undergoing major ablative and ablative-reconstructive oncologic surgery for head and neck tumours. Overall, 8 adult patients (2 female, 6 male) have been treated. Six cases were affected by pharyngocutaneous fistulas, one by severe sialorrhoea and one recurrent sialocele. After the injection, patients were regularly observed at follow-up and asked to give their subjective assessment of salivary flow. Investigations concerning possible complaints, including side-effects, as well as complete examination of the head and neck area were performed. Follow-up periods ranged from 12 to 24 weeks (mean 20 weeks). Following botulinum neurotoxin injection, the fistula was dry after a mean period of 4.5 days (min 3 days, max 8 days) and was closed 6.6 days (min 5 days, max 8 days) later. The patient affected by severe hypersalivation reported subjective improvement in sialorrhoea 4 days post-treatment. The patient affected by recurrent sialocele, required only one aspiration of fluid two days after the treatment, after which there were no further problems. Post-operative saliva-related complications significantly increase patient morbidity and hospital stay after major tumour surgery. The easy, safe and effective treatment with botulinum neurotoxin injection, observed in our experience, suggest its significant role as a useful option in the post-operative saliva-related complications.
M R Marchese; G Almadori; A Giorgio; G Paludetti
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale     Volume:  28     ISSN:  0392-100X     ISO Abbreviation:  Acta Otorhinolaryngol Ital     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-06-06     Completed Date:  2008-10-03     Revised Date:  2010-09-21    
Medline Journal Info:
Nlm Unique ID:  8213019     Medline TA:  Acta Otorhinolaryngol Ital     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  13-6     Citation Subset:  IM    
Institute of Otorhinolaryngology, "A. Gemelli" Hospital, Catholic University of the Sacred Heart, Rome, Italy.
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MeSH Terms
Botulinum Toxin Type A / administration & dosage*
Head and Neck Neoplasms / surgery*
Middle Aged
Neurotoxins / administration & dosage*
Postoperative Complications / prevention & control*
Sialorrhea / prevention & control*
Reg. No./Substance:
0/Botulinum Toxin Type A; 0/Neurotoxins

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