| Post-stroke dementia: the contribution of thalamus and basal ganglia changes. | |
| | |
MedLine Citation:
|
PMID: 22153202 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
ABSTRACTBackground: The neurobiological basis of increased risk of dementia in stroke patients is unclear, though there are several related pathological changes, including white matter hyperintensities (WMH), and medial temporal atrophy. Subcortical gray matter structures have also been implicated in dementia resulting from vascular pathology, particularly vascular dementia. This study aimed to investigate the contribution of changes in subcortical gray matter structures to post-stroke dementia (PSD).Methods: T1- and T2-weighted images and T2-weighted fluid-attenuated inversion recovery (FLAIR) images were obtained on a 3-Tesla magnetic resonance (MR) system, in four groups aged over 75 years: post-stroke with dementia (PSD; 8), post-stroke no dementia (PSnoD; 33), Alzheimer's disease (AD; 26) and controls (30). Automated software was used to measure the volume of thalamus, putamen, caudate nucleus, and hippocampus as well as total WMH volume. The number of subcortical lacunes was also counted.Results: The number of caudate lacunes was higher in the PSnoD group, compared with AD (p = 0.029) and controls (p = 0.019). The putamen volume was smaller in the stroke and AD groups, when compared with controls. In the whole stroke group, putamen lacunes were correlated with impairment in memory (Rey test; ρ = -0.365; p = 0.031), while WMH and hippocampal volume both correlated with global dysfunction.Conclusion: Our findings implicate a variety of neurobiological substrates of dementia, such as small vessel disease and Alzheimer pathology, which develop after stroke in an old older population, with a contribution from subcortical brain structures. |
| | |
Authors:
|
Marcos Antonio Lopes; Michael J Firbank; Michelle Widdrington; Andrew M Blamire; Raj N Kalaria; John T O'Brien |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-12-12 |
Journal Detail:
|
Title: International psychogeriatrics / IPA Volume: - ISSN: 1741-203X ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2011-12-13 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9007918 Medline TA: Int Psychogeriatr Country: - |
Other Details:
|
Languages: ENG Pagination: 1-9 Citation Subset: - |
Affiliation:
|
Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Self-deception's adaptive value: Effects of positive thinking and the winner effect.
Next Document: The effects of working height and manipulated weights on subjective strain, body posture and muscula...