| Post-prandial iron absorption in humans: comparison between HFE genotypes and iron deficiency anaemia. | |
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MedLine Citation:
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PMID: 18276042 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND & AIMS: Measurement of serum iron increase after ingestion of a meal could be an efficient method of comparing post-prandial iron absorption between groups of individuals. We determined whether the rise in post-prandial serum iron is increased in fully treated patients with hereditary haemochromatosis (HFE C282Y+/+; HH) compared to iron deficiency anaemia (IDA), iron-replete heterozygous subjects (HFE C282Y+/-) and iron-replete controls (HFE C282Y-/-). METHODS: Serum iron increase was measured over 4h after a meal containing 13.1 mg non-haem iron. RESULTS: Post-prandial increase in serum iron was similar in treated HH versus IDA (P=0.54), but greater than control subjects (P<0.0001). In five HH patients, using (58)Fe as a tracer, the rate of iron absorption was increased (P<0.05) and serum non-transferrin bound iron showed a tendency to increase (P=0.06). Serum iron curves did not differ for heterozygous subjects and controls (P=0.65). CONCLUSIONS: Using the serum iron method we found a comparable increase in post-prandial iron absorption in treated HH and IDA compared with controls. While post-prandial iron absorption in the group heterozygous for the C282Y mutation was modestly increased relative to controls, this difference was not statistically significant. |
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Authors:
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Carol Hutchinson; Rana E Conway; Adrian Bomford; Robert C Hider; Jonathan J Powell; Catherine A Geissler |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-02-13 |
Journal Detail:
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Title: Clinical nutrition (Edinburgh, Scotland) Volume: 27 ISSN: 1532-1983 ISO Abbreviation: Clin Nutr Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-04-08 Completed Date: 2008-05-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8309603 Medline TA: Clin Nutr Country: England |
Other Details:
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Languages: eng Pagination: 258-63 Citation Subset: IM |
Affiliation:
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The Iron Metabolism Interdisciplinary Research Group, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9HN, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anemia, Iron-Deficiency / blood, metabolism* Area Under Curve Female Ferritins / blood Genotype Hemochromatosis / blood, genetics*, metabolism* Hemoglobins / metabolism Heterozygote Histocompatibility Antigens Class I / genetics Humans Intestinal Absorption Iron / blood* Iron Isotopes Iron, Dietary / pharmacokinetics* Male Membrane Proteins / genetics Middle Aged Mutation Postprandial Period |
| Chemical | |
Reg. No./Substance:
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0/HFE protein, human; 0/Hemoglobins; 0/Histocompatibility Antigens Class I; 0/Iron Isotopes; 0/Iron, Dietary; 0/Membrane Proteins; 7439-89-6/Iron; 9007-73-2/Ferritins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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