| Post-operative Treatment with Cisplatin and Vinorelbine in Chinese Patients with Non-small Cell Lung Cancer: A Clinical Prospective Analysis of 451 Patients. | |
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MedLine Citation:
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PMID: 23167369 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Purpose: To determine the efficacy of post-operative chemotherapy with cisplatin plus vinorelbine (NP) in Chinese patients with non-small cell lung cancer (NSCLC). Methods: A total of 451 patients with NSCLCs at stages I, II, and IIIA after surgical resection were treated with cisplatin plus vinorelbine for 4 cycles or volunteers observed between January 2002 and November 2004 and were followed for five years. The therapeutic efficacy was evaluated with reference to overall survival (OS) and disease-free survival (DFS), and adverse effects were also recorded. Potential factors affecting the lengths of OS and DFS were analyzed by multivariate analysis. Results: Most patients (86.7%) completed at least 4 cycles of treatment. Patients with chemotherapy survived significantly longer than those in the observation group (p<0.001). The absolute improvements in the 2 and 5-year OS were 3.8% [hazard ratio (HR) =0.674, 95% confidence interval (CI): 0.554-0.820, P<0.0001] and 13.0% (HR=0.732, 95% CI: 0.579-0.926, P=0.009), respectively. The improvement at 4-year DFS was 2.1% (HR=0.327, 95% CI: 0.214-0.500, P<0.0001). Stratification analysis revealed that older age, histological type, pathological degree, but not the gender and smoking status, are independent factors affecting the length of survival in this population. Many patients (63.3%) had grade 1-III tolerable adverse effects, and there was no treatment-related death. Conclusions: Post-operative chemotherapy with NP regimen is effective and tolerable in Chinese patients with NSCLC. |
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Authors:
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Jing Wang; Feng Liu; Deng-Xiao Huang; Bin Jiang |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Asian Pacific journal of cancer prevention : APJCP Volume: 13 ISSN: 1513-7368 ISO Abbreviation: Asian Pac. J. Cancer Prev. Publication Date: 2012 |
Date Detail:
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Created Date: 2012-11-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101130625 Medline TA: Asian Pac J Cancer Prev Country: Thailand |
Other Details:
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Languages: eng Pagination: 4505-10 Citation Subset: IM |
Affiliation:
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Department of Oncology, No.3 People's Hospital Affiliated to Shanghai Jiao-Tong University School of Medicine (SJTU-SM), Shanghai, China E-mail : jiangbinwcr@yahoo.com.cn. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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