Document Detail

Post-neonatal drop in alveolar SP-A expression: biological significance for increased vulnerability to SIDS?
MedLine Citation:
PMID:  18085709     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Surfactant protein A (SP-A) is synthesized in the lung and is a part of the innate immune system. The aim of this study was to evaluate the expression of SP-A in lung tissue from fetuses, infants, children and adults with special regard to sudden infant death syndrome (SIDS). METHODS: A total of 160 cases were studied; 19 fetuses and neonates, 59 SIDS and 49 explained infant deaths below 1 year of age, 19 toddlers and 14 adults. Immunohistochemical detection of SP-A using monoclonal antibodies was performed by microscopy of lung tissue specimens collected at autopsy. A scoring system was developed enabling semi-quantitative estimation of staining intensity and distribution. RESULTS: SP-A was detected in the terminal bronchioles and alveolar spaces of fetuses >35 weeks gestation. The intra-alveolar SP-A expression increased in the perinatal period followed by a marked drop in infants aged between 1 week and 5 months. Infants aged >5 months had abundant SP-A expression corresponding to older children and adults. There was no difference in the age distribution between cases of SIDS and explained deaths. CONCLUSIONS: The apparent drop in SP-A expression takes place in the first months after birth, corresponding with the classical age peak of SIDS. We therefore hypothesize that low expression of SP-A may be related in some as-yet undetermined way to the increased risk of SIDS at that age.
Arne Stray-Pedersen; Ashild Vege; Asbjorg Stray-Pedersen; Uffe Holmskov; Torleiv Ole Rognum
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric pulmonology     Volume:  43     ISSN:  1099-0496     ISO Abbreviation:  Pediatr. Pulmonol.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-01-02     Completed Date:  2008-03-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8510590     Medline TA:  Pediatr Pulmonol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  160-8     Citation Subset:  IM    
Copyright Information:
Copyright 2007 Wiley-Liss, Inc.
Institute of Forensic Medicine, University of Oslo, Rikshospitalet, Oslo, Norway.
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MeSH Terms
Age Distribution
Age Factors
Antibodies, Monoclonal / diagnostic use
Biological Markers / analysis
Child, Preschool
Fetal Death*
Fetus / chemistry*
Infant, Newborn
Norway / epidemiology
Observer Variation
Pulmonary Alveoli / chemistry*
Pulmonary Surfactant-Associated Protein A / analysis*
Reproducibility of Results
Risk Assessment
Risk Factors
Sudden Infant Death / etiology*
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Biological Markers; 0/Pulmonary Surfactant-Associated Protein A

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