Document Detail


Post-myocardial infarction left ventricular myocyte remodeling: are there gender differences in rats?
MedLine Citation:
PMID:  21081276     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Previous studies have shown gender differences in left ventricular remodeling after myocardial infarction. Results are varied, however, and reliable, comprehensive data for changes in cardiac myocyte shape are not available.
METHODS: Young adult female and male Sprague-Dawley rats were used in this study and randomly assigned to the myocardial infarction and sham myocardial infarction groups. Myocardial infarction was produced by ligation of the left descending coronary artery. Four weeks after surgery, left ventricular echocardiography and hemodynamics were performed before isolating myocytes for size determination.
RESULTS: In general, left ventricular functional changes after myocardial infarction were comparable. Females developed slightly, but significantly, more left ventricular hypertrophy than males, and this was reflected by the relative increases in left ventricular myocyte volume. In both males and females, however, myocyte hypertrophy was due exclusively to lengthening of myocytes with no change in myocyte cross-sectional area.
CONCLUSIONS: This study demonstrates that post-myocardial infarction changes in LV function and myocyte remodeling are remarkably similar in young adult male and female rats.
Authors:
Yue-Feng Chen; Rebecca A Redetzke; Ryan M Sivertson; Tamora S Coburn; Luke R Cypher; Anthony Martin Gerdes
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Publication Detail:
Type:  Journal Article     Date:  2010-11-16
Journal Detail:
Title:  Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology     Volume:  20     ISSN:  1879-1336     ISO Abbreviation:  Cardiovasc. Pathol.     Publication Date:    2011 Sep-Oct
Date Detail:
Created Date:  2011-09-06     Completed Date:  2012-01-05     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  9212060     Medline TA:  Cardiovasc Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e189-95     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Affiliation:
Cardiovascular Health Research Center, Sanford Research/University of South Dakota, 1100 East 21st Street, Suite 700, Sioux Falls, SD 57105, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Disease Models, Animal
Echocardiography
Female
Hemodynamics
Male
Myocardial Infarction / pathology*,  physiopathology
Myocytes, Cardiac / pathology*
Rats
Rats, Sprague-Dawley
Sex Factors
Ventricular Function, Left
Ventricular Remodeling*
Grant Support
ID/Acronym/Agency:
P20 RR017662-06A16772/RR/NCRR NIH HHS; P20 RR017662-07/RR/NCRR NIH HHS; P20 RR017662-075906/RR/NCRR NIH HHS
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