Document Detail


Post-mortem stability and redistribution of carbohydrate-deficient transferrin (CDT).
MedLine Citation:
PMID:  17475426     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Post-mortem diagnosis of chronic alcohol abuse is a challenge for forensic experts due to the lack of pathognomonic morphological findings and often also inadequate background information. Objective methods demonstrating chronic excessive alcohol consumption would therefore be a useful tool for forensic pathologists. In clinical practice, several markers of chronic alcohol abuse have recently been introduced, among which carbohydrate-deficient transferrin (CDT) is the most accepted, but the use of these markers in autopsy has not yet been established. We examined post-mortem stability and possible post-mortem redistribution of CDT and compared two analytical methods, capillary zone electrophoresis and high-performance liquid chromatography. According to our results, CDT remains stable for an appreciable time after death. The results further indicate that CDT is not subject to major post-mortem redistribution.
Authors:
Juha Rainio; Giorgia De Paoli; Henrik Druid; Riitta Kauppila; Fabio De Giorgio; Federica Bortolotti; Franco Tagliaro
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Publication Detail:
Type:  Journal Article     Date:  2007-05-01
Journal Detail:
Title:  Forensic science international     Volume:  174     ISSN:  1872-6283     ISO Abbreviation:  Forensic Sci. Int.     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-01-14     Completed Date:  2008-02-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7902034     Medline TA:  Forensic Sci Int     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  161-5     Citation Subset:  IM    
Affiliation:
Institute of Legal Medicine, Catholic University of Sacred Heart School of Medicine, Rome, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Alcoholism / diagnosis,  metabolism
Biological Markers
Chromatography, High Pressure Liquid
Electrophoresis, Capillary
Female
Forensic Toxicology*
Humans
Male
Middle Aged
Postmortem Changes*
Transferrin / analogs & derivatives*,  metabolism
Chemical
Reg. No./Substance:
0/Biological Markers; 0/carbohydrate-deficient transferrin; 11096-37-0/Transferrin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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