| Post-mortem stability and redistribution of carbohydrate-deficient transferrin (CDT). | |
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MedLine Citation:
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PMID: 17475426 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Post-mortem diagnosis of chronic alcohol abuse is a challenge for forensic experts due to the lack of pathognomonic morphological findings and often also inadequate background information. Objective methods demonstrating chronic excessive alcohol consumption would therefore be a useful tool for forensic pathologists. In clinical practice, several markers of chronic alcohol abuse have recently been introduced, among which carbohydrate-deficient transferrin (CDT) is the most accepted, but the use of these markers in autopsy has not yet been established. We examined post-mortem stability and possible post-mortem redistribution of CDT and compared two analytical methods, capillary zone electrophoresis and high-performance liquid chromatography. According to our results, CDT remains stable for an appreciable time after death. The results further indicate that CDT is not subject to major post-mortem redistribution. |
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Authors:
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Juha Rainio; Giorgia De Paoli; Henrik Druid; Riitta Kauppila; Fabio De Giorgio; Federica Bortolotti; Franco Tagliaro |
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Publication Detail:
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Type: Journal Article Date: 2007-05-01 |
Journal Detail:
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Title: Forensic science international Volume: 174 ISSN: 1872-6283 ISO Abbreviation: Forensic Sci. Int. Publication Date: 2008 Jan |
Date Detail:
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Created Date: 2008-01-14 Completed Date: 2008-02-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7902034 Medline TA: Forensic Sci Int Country: Ireland |
Other Details:
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Languages: eng Pagination: 161-5 Citation Subset: IM |
Affiliation:
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Institute of Legal Medicine, Catholic University of Sacred Heart School of Medicine, Rome, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Alcoholism / diagnosis, metabolism Biological Markers Chromatography, High Pressure Liquid Electrophoresis, Capillary Female Forensic Toxicology* Humans Male Middle Aged Postmortem Changes* Transferrin / analogs & derivatives*, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/carbohydrate-deficient transferrin; 11096-37-0/Transferrin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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