Document Detail


Post-mortem distribution and tissue concentrations of digoxin in infants and adults.
MedLine Citation:
PMID:  1155068     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
By means of 86Rb uptake inhibition assay, the distribution and tissue concentrations of digoxin in various tissues during maintenance therapy were studied post mortem in 12 infants (aged 5 days to 8 months) and 17 adults (aged 49-91 years). The mean maintenance dose for infants was 0.014 mg/kg bw/24 h and for adults, 0.005 mg/kg bw/24 h. The same relative distribution of the glycoside found in infants and in adults was: choroid plexus greater than ventricular myocardium greater than kidney greater than liver greater than skeletal muscle. Between infants and adults, the mean digoxin concentrations in choroid plexus, kidney, liver, and skeletal muscle did not differ significantly; however, significant differences were found in the glycoside concentrations in ventricular and in atrial myocardium. Both infants and adults showed a difference in the content of the glycoside within the heart, the concentration in ventricular muscle being significantly higher than in atrial. There seemed to be no direct relation between the tissue concentrations of the glycoside (myocardium, skeletal muscle) and the daily maintenance dose/mg/kg bw/24 h). The results suggest that the myocardial binding of digoxin is higher in infants than in adults.
Authors:
K E Andersson; A Bertler; G Wettrell
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta paediatrica Scandinavica     Volume:  64     ISSN:  0001-656X     ISO Abbreviation:  Acta Paediatr Scand     Publication Date:  1975 May 
Date Detail:
Created Date:  1975-11-08     Completed Date:  1975-11-08     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0000211     Medline TA:  Acta Paediatr Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  497-504     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / metabolism
Aged
Autopsy
Binding Sites
Brain / metabolism
Choroid Plexus / metabolism
Digoxin / blood,  metabolism*
Female
Humans
Infant
Infant, Newborn
Kidney / metabolism
Liver / metabolism
Male
Middle Aged
Muscles / metabolism
Myocardium / metabolism
Rubidium / metabolism
Chemical
Reg. No./Substance:
20830-75-5/Digoxin; 7440-17-7/Rubidium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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