Document Detail

Post-kala-azar dermal leishmaniasis: a clinical and therapeutic study.
MedLine Citation:
PMID:  8387467     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Post-kala-azar dermal leishmaniasis is a condition peculiarly confined to the Indian subcontinent. METHODS: The clinical features and investigations in 18 patients of post-kala-azar dermal leishmaniasis were studied. RESULTS: There was a polymorphic picture from hypopigmented macules to nodules and plaques. Mucous membranes were affected in five, the lips and glans penis being the most frequent sites. Histopathologically, a rich dermal infiltrate was seen in indurated lesions and in macules; it was confined to perivascular foci in the upper dermis. Leishman-Donovan bodies were seen in 16. CONCLUSIONS: The lesions cleared in 4 to 5 months after treatment with sodium antimony gluconate intramuscularly 20 mg/kg/day up to a maximum of 1 g/day. The drug was well tolerated.
V Ramesh; R S Misra; U Saxena; A Mukherjee
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of dermatology     Volume:  32     ISSN:  0011-9059     ISO Abbreviation:  Int. J. Dermatol.     Publication Date:  1993 Apr 
Date Detail:
Created Date:  1993-06-08     Completed Date:  1993-06-08     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  0243704     Medline TA:  Int J Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  272-5     Citation Subset:  IM    
Department of Dermatology and Leprology, Safdarjang Hospital, New Delhi, India.
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MeSH Terms
Antimony Sodium Gluconate / therapeutic use*
Diagnostic Tests, Routine
Follow-Up Studies
Leishmaniasis, Cutaneous* / diagnosis,  drug therapy,  etiology
Leishmaniasis, Visceral / complications*
Middle Aged
Skin / pathology*
Reg. No./Substance:
0/Antimony Sodium Gluconate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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