Document Detail


Post-ischaemic cardiac dilatation and remodelling: reperfusion injury of the interstitium.
MedLine Citation:
PMID:  8370359     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cardiac size and geometry have an important influence on clinical prognosis in heart disease. The cardiac interstitium would appear to play a major role in modulating muscle configuration after ischaemic insults. Ischaemic reperfusion injury of the heart should not be viewed as confined to the myocyte compartment. There are major events occurring in the interstitial compartment which could ultimately determine the long-term configuration and topography of the heart. Thus, permanent plastic changes in cardiac dimensions appear to evolve after initial alterations in the collagen matrix. The physiological, cellular, biochemical, and molecular considerations in the cardiac interstitium are quite different from those of the myocyte compartment. Accordingly, therapeutic interventions to modulate cardiac geometry and remodelling may differ.
Authors:
C Eng; M Zhao; S M Factor; E H Sonnenblick
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  European heart journal     Volume:  14 Suppl A     ISSN:  0195-668X     ISO Abbreviation:  Eur. Heart J.     Publication Date:  1993 Jul 
Date Detail:
Created Date:  1993-10-14     Completed Date:  1993-10-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  27-32     Citation Subset:  IM    
Affiliation:
Cardiovascular Research Laboratories, Albert Einstein College of Medicine, Bronx, New York.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cardiac Volume / physiology
Cardiomegaly / pathology*
Collagen / metabolism
Coronary Circulation / physiology*
Heart Failure / pathology
Hemodynamics / physiology
Humans
Myocardial Ischemia / pathology*
Myocardial Reperfusion Injury / pathology*
Myocardium / pathology*
Ventricular Function, Left / physiology
Chemical
Reg. No./Substance:
9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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