| Post-intervention IVUS is not predictive for very late in-stent thrombosis in drug-eluting stents. | |
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MedLine Citation:
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PMID: 20058506 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Stent thrombosis is a life-threatening complication associated with sudden death and acute myocardial infarction. Histopathologic studies have linked the occurrence of very late stent thrombosis in drug-eluting stents (DES) with delayed endothealisation and stent malapposition. Our aim was to investigate if late stent malapposition in DES could be predicted by immediate postintervention intra-vascular ultrasonography (IVUS). METHODS AND RESULTS: From our MISSION! database of 184 consecutive patients with ST-elevation myocardial infarction (STEMI) who had immediate post-intervention and nine-month follow-up IVUS examinations we prospectively identified three patients with very late (> 365 days) and definite (with angiographic evidence) in-stent thrombosis in DES. Patients had completed the twelve-month clopidogrel-aspirin dual treatment period, two of them were under aspirin therapy while the third patient had aspirin temporarily discontinued before planned surgery. When assessed by serial documentary (immediate post-intervention and nine-month) IVUS, all three patients demonstrated stent malapposition at nine months: in two cases the malapposition was acquired (immediate post-intervention IVUS showed a well apposed stent) and one case presented persistent malapposition (the stent was found malapposed both at immediate post-intervention and nine-month follow-up IVUS). CONCLUSIONS: Immediate post-intervention IVUS showing no malapposition does not guarantee an uneventful course after DES implantation. |
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Authors:
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Sandrin C Bergheanu; Bas L Van der Hoeven; Ayman K M Hassan; Jouke Dijkstra; Frits R Rosendaal; Su-San Liem; Martin J Schalij; Johanna G Van der Bom; J Wouter Jukema |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta cardiologica Volume: 64 ISSN: 0001-5385 ISO Abbreviation: Acta Cardiol Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2010-01-11 Completed Date: 2010-02-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370570 Medline TA: Acta Cardiol Country: Belgium |
Other Details:
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Languages: eng Pagination: 611-6 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged, 80 and over Angioplasty, Transluminal, Percutaneous Coronary / adverse effects* Coronary Angiography Coronary Thrombosis / etiology, radiography, ultrasonography* Drug-Eluting Stents / adverse effects* Electrocardiography Female Follow-Up Studies Humans Male Middle Aged Myocardial Infarction / diagnosis, surgery* Predictive Value of Tests Prosthesis Failure Time Factors Ultrasonography, Interventional / methods* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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