Document Detail

Post-exercise vitamin C supplementation and recovery from demanding exercise.
MedLine Citation:
PMID:  12682838     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to investigate whether post-exercise vitamin C supplementation influences recovery from an unaccustomed bout of exercise. Sixteen male subjects were allocated to either a placebo (P; n=8) or vitamin C (VC) group ( n=8). Subjects performed a prolonged (90-min) intermittent shuttle-running test, and supplementation began after the cessation of exercise. Immediately after exercise the VC group consumed 200 mg of VC dissolved in a 500 ml drink, whereas the subjects in the P group consumed the drink alone. Later on the same day and then in the morning and evening of the following 2 days, subjects consumed additional identical drinks. Plasma VC concentrations in the VC group increased above those in the P group 1 h after exercise and remained above P values for the 3 days after exercise. Nevertheless, post-exercise VC supplementation was not associated with improved recovery. Post-exercise serum creatine kinase activities and myoglobin concentrations were unaffected by supplementation. Muscle soreness and the recovery of muscle function in the leg flexors and extensors were not different in VC and P groups. Furthermore, although plasma concentrations of interleukin-6 and malondialdehyde increased following exercise, there was no difference between VC and P groups. These results suggest that either free radicals are not involved in delaying the recovery process following a bout of unaccustomed exercise, or that the consumption of VC wholly after exercise is unable to deliver this antioxidant to the appropriate sites with sufficient expediency to improve recovery.
D Thompson; C Williams; P Garcia-Roves; S J McGregor; F McArdle; M J Jackson
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2003-04-01
Journal Detail:
Title:  European journal of applied physiology     Volume:  89     ISSN:  1439-6319     ISO Abbreviation:  Eur. J. Appl. Physiol.     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-05-08     Completed Date:  2004-02-27     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  100954790     Medline TA:  Eur J Appl Physiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  393-400     Citation Subset:  IM    
Department of Sport and Exercise Science, University of Bath, Bath BA2 7AY, UK.
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MeSH Terms
Adaptation, Physiological / drug effects
Administration, Oral
Antioxidants / administration & dosage,  analysis
Ascorbic Acid / administration & dosage*,  blood
Dietary Supplements
Double-Blind Method
Interleukin-6 / blood
Leg / physiopathology
Malondialdehyde / blood
Muscle Contraction / physiology
Muscle Fatigue / drug effects*
Muscle, Skeletal / drug effects*,  injuries,  physiopathology*
Pain / physiopathology,  prevention & control
Physical Exertion / drug effects*
Recovery of Function / drug effects*
Running / physiology*
Reg. No./Substance:
0/Antioxidants; 0/Interleukin-6; 50-81-7/Ascorbic Acid; 542-78-9/Malondialdehyde

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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