| Post-exercise lactate metabolism: a comparative review of sites, pathways, and regulation. | |
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MedLine Citation:
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PMID: 8815809 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Most vertebrates utilize supplemental lactate production to support the energetic demands of vigorous, brief exercise. Despite similar patterns of accumulation, there appears to be a trichotomy with regards to lactate processing post-exercise. Most fish retain most of their lactate intramuscularly, using it for in situ glycogen replenishment. Recent evaluation of fish muscle concludes that pyruvate kinase reversal is a probable gluconeogenic pathway. Amphibians and reptiles also utilize lactate as a muscle glyconeogenic substrate, but lactate is not sequestered post-exercise. None of these groups utilize hepatic gluconeogenesis to any significant extent post-exercise, and muscle glucose uptake is limited. Lactate oxidation plays a major role post-exercise in mammals, with hepatic and muscular gluco- and glyconeogenesis contributing to a lesser extent. Glucocorticoids may regulate lactate release from fish muscle, although catecholamines may influence glyconeogenesis in reptile muscle. Insulin affects lactate metabolism indirectly through its effects on muscle glucose metabolism. |
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Authors:
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T T Gleeson |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Annual review of physiology Volume: 58 ISSN: 0066-4278 ISO Abbreviation: Annu. Rev. Physiol. Publication Date: 1996 |
Date Detail:
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Created Date: 1996-10-04 Completed Date: 1996-10-04 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0370600 Medline TA: Annu Rev Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 565-81 Citation Subset: IM |
Affiliation:
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Environmental, Population, and Organismic Biology, University of Colorado, Boulder 80309-0334, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Exercise / physiology* Humans Lactates / metabolism* Physical Exertion / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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R01 DK46408/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Lactates |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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