Document Detail

Post-exercise hypotension and sustained post-exercise vasodilation: What happens after we exercise?
MedLine Citation:
PMID:  22872658     Owner:  NLM     Status:  Publisher    
A single bout of aerobic exercise produces a post-exercise hypotension associated with a sustained post-exercise vasodilation of the previously exercised muscle. Work over the last few years has determined key pathways for the obligatory components of post-exercise hypotension and sustained post-exercise vasodilation and points the way to possible benefits that may result from these robust responses. During the exercise recovery period, the combination of centrally mediated decreases in sympathetic nerve activity, in addition to a reduced signal transduction from sympathetic nerve activation into vasoconstriction, and local vasodilator mechanisms contribute to the fall in arterial blood pressure seen after exercise. Important findings from recent studies include the recognition that 1) skeletal muscle afferents may play a primary role in post-exercise resetting of the baroreflex via discrete receptor changes within the nucleus tractus solitarii (NTS), and 2) sustained post-exercise vasodilation of the previously active skeletal muscle is primarily the result of histamine H1- and H2-receptor activation. Future research directions include further exploration of the potential benefits of these changes in the longer term adaptations associated with exercise training, as well as investigation of how the recovery from exercise may provide windows of opportunity for targeted interventions in patients with hypertension and diabetes.
John Halliwill; Tahisha M Buck; Alisha N Lacewell; Steven A Romero
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-7
Journal Detail:
Title:  Experimental physiology     Volume:  -     ISSN:  1469-445X     ISO Abbreviation:  Exp. Physiol.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9002940     Medline TA:  Exp Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
University of Oregon.
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