Document Detail


Post-embryonic pericardial cells of Drosophila are required for overcoming toxic stress but not for cardiac function or adult development.
MedLine Citation:
PMID:  17987318     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The Drosophila heart is composed of two cell types: cardioblasts (CB) and pericardial cells (PC). Whereas CBs act to maintain rhythmic contractions, the functions of accessory PCs are not clear. The close association between these two cell types has led to speculation of a cardio-regulatory role for PCs. However, we find that viability and cardiac function are normal in larvae following post-embryonic ablation of PCs by induced cell death. Removal of PCs during the larval instars or before metamorphosis results in viable and fertile adults. Interestingly, such animals have a reduced lifespan and increased sensitivity to toxic chemicals. Thus, although PCs may have an embryonic role in cardiogenesis, they do not appear to play a part later in cardiac function as suggested. However, the role of PCs in the uptake and sequestering of toxins, their sensitivity to toxic stress and the decreased lifespan of animals without PCs indicate the importance of PCs in organismal homeostasis.
Authors:
Debjani Das; Rajaguru Aradhya; D Ashoka; Maneesha Inamdar
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-11-07
Journal Detail:
Title:  Cell and tissue research     Volume:  331     ISSN:  0302-766X     ISO Abbreviation:  Cell Tissue Res.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-01-11     Completed Date:  2008-05-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0417625     Medline TA:  Cell Tissue Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  565-70     Citation Subset:  IM    
Affiliation:
Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur P.O., Bangalore, 560064, India.
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MeSH Terms
Descriptor/Qualifier:
Animals
DNA Damage*
Drosophila melanogaster* / anatomy & histology,  embryology,  growth & development
Heart / growth & development
Heart Rate
Life Expectancy
Metamorphosis, Biological
Myocardium / cytology

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