| Post-cardiac arrest temperature manipulation alters early EEG bursting in rats. | |
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MedLine Citation:
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PMID: 18597914 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Hypothermia improves outcomes after cardiac arrest (CA), while hyperthermia worsens injury. EEG recovers through periodic bursting from isoelectricity after CA, the duration of which is associated with outcome in normothermia. We quantified burst frequency to study the effect of temperature on early EEG recovery after CA. METHODS: Twenty-four rats were divided into three groups, based on 6h of hypothermia (T=33 degrees C), normothermia (T=37 degrees C), or hyperthermia (T=39 degrees C) immediately post-resuscitation from 7-min asphyxial CA. Temperature was maintained using surface cooling and re-warming. Neurological recovery was defined by 72-h neurological deficit score (NDS). RESULTS: Burst frequency was higher during the first 90min in rats treated with hypothermia (25.6+/-12.2min(-1)) and hyperthermia (22.6+/-8.3min(-1)) compared to normothermia (16.9+/-8.5min(-1)) (p<0.001). Burst frequency correlated strongly with 72-h NDS in normothermic rats (p<0.05) but not in hypothermic or hyperthermic rats. The 72-h NDS of the hypothermia group (74, 61-74; median, 25-75th percentile) was significantly higher than the normothermia (49, 47-61) and hyperthermia (43, 0-50) groups (p<0.001). CONCLUSIONS: In normothermic rats resuscitated from CA, early EEG burst frequency is strongly associated with neurological recovery. Increased bursting followed by earlier restitution of continuous EEG activity with hypothermia may represent enhanced recovery, while heightened metabolic rate and worsening secondary injury is likely in the hyperthermia group. These factors may confound use of early burst frequency for outcome prediction. |
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Authors:
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Xiaofeng Jia; Matthew A Koenig; Anand Venkatraman; Nitish V Thakor; Romergryko G Geocadin |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2008-07-01 |
Journal Detail:
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Title: Resuscitation Volume: 78 ISSN: 0300-9572 ISO Abbreviation: Resuscitation Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-08-04 Completed Date: 2009-01-27 Revised Date: 2012-01-06 |
Medline Journal Info:
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Nlm Unique ID: 0332173 Medline TA: Resuscitation Country: Ireland |
Other Details:
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Languages: eng Pagination: 367-73 Citation Subset: IM |
Affiliation:
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Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. xjia1@jhmi.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / physiopathology* Cardiopulmonary Resuscitation* Electroencephalography* Heart Arrest / complications, physiopathology*, therapy* Hyperthermia, Induced* Hypothermia, Induced* Male Rats Rats, Wistar Recovery of Function |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL071568/HL/NHLBI NIH HHS; R01 HL071568-05/HL/NHLBI NIH HHS; R01 HL071568-09/HL/NHLBI NIH HHS; R21 NS054146/NS/NINDS NIH HHS; R21 NS054146-02/NS/NINDS NIH HHS |
| Comments/Corrections | |
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