Document Detail

Post-anaesthetic maternal death in a patient with mediastinal large B-cell lymphoma: a case report.
MedLine Citation:
PMID:  17345895     Owner:  NLM     Status:  MEDLINE    
A 32-year-old female underwent laparoscopic salpingectomy of an ectopic (third) pregnancy under general anaesthesia, at approximately six weeks' amenorrhoea. She developed severe respiratory distress after extubation and died on the second postoperative day. It appears that she had a history of a mild, persistent productive cough for a period of about a month prior to the operation that was attributed to an upper respiratory tract infection. Autopsy demonstrated the presence of a large mediastinal tumour, whose existence was apparently unsuspected preoperatively, encasing the ascending thoracic aorta, aortic arch and the proximal segments of the brachiocephalic and subclavian arteries, and causing extrinsic airway compression. Subsequent microscopic examination showed histological and immunohistochemical features of a mediastinal large B-cell lymphoma. It is thought that the mechanical effects exerted by the advanced mediastinal tumour upon the airways and the thoracic cage, coupled with the pathophysiological effects of general anaesthesia on respiratory movement and airway patency, had led to the patient's unfortunate demise in early pregnancy.
Gilbert Lau
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Medicine, science, and the law     Volume:  47     ISSN:  0025-8024     ISO Abbreviation:  Med Sci Law     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-03-09     Completed Date:  2007-04-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0400721     Medline TA:  Med Sci Law     Country:  England    
Other Details:
Languages:  eng     Pagination:  74-8     Citation Subset:  IM    
Centre for Forensic Medicine, Singapore.
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MeSH Terms
Lymphoma, B-Cell / pathology*
Maternal Mortality*
Mediastinal Neoplasms / physiopathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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