Document Detail


Post-Translational Isoprenylation of Tryptophan.
MedLine Citation:
PMID:  21821957     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Bacillus subtilis and related bacilli produce a post-translationally modified oligopeptide, ComX pheromone, that stimulates natural genetic competence controlled by quorum sensing. The ComX pheromones are formed by geranylation or farnesylation on a tryptophan residue at the 3 position of its indole ring. This results in the formation of a tricyclic structure including, a newly formed five-membered ring, similar to proline. Isoprenylation of ComX to form ComX pheromones is essential for pheromonal activity, and is functionally more crucial than its amino acid sequence. The ComX pheromone is the first example of isoprenoidal modifiations of tryptophan residues in living organisms and post-translational isoprenylation of any amino acid in prokaryotes. Because the presence of geranylated compounds is unusual in primary and secondary metabolites outside the plant kingdom, post-translational geranylation in bacilli is unprecedented in nature.
Authors:
Masahiro Okada
Related Documents :
15997857 - Analysis of aristolochic acids and analogues in medicinal plants and their commercial p...
21124057 - The in vitro antioxidant properties of chinese highland lichens.
1632527 - A spectrophotometric microtiter-based assay for the detection of hydroperoxy derivative...
3338147 - Chemical assay of p-aminohippuric acid simplified by use of dimethylaminocinnamaldehyde...
6603257 - Intrathecal vincristine. report of a fatal case despite cns washout.
16198047 - A quantum chemical study on the mechanism of glycinamide ribonucleotide transformylase ...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-7
Journal Detail:
Title:  Bioscience, biotechnology, and biochemistry     Volume:  -     ISSN:  1347-6947     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-8-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205717     Medline TA:  Biosci Biotechnol Biochem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Chemistry, Graduate School of Science, Tohoku University.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Fritillaria ussuriensis Extract Inhibits the Production of Inflammatory Cytokine and MAPKs in Mast C...
Next Document:  Synthesis of Microbial Signaling Molecules and Their Stereochemistry-Activity Relationships.