Document Detail


Post-reperfusion enhancement of CD14(+)CD16(-) monocytes and microvascular obstruction in ST-segment elevation acute myocardial infarction.
MedLine Citation:
PMID:  20453385     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The presence of microvascular obstruction (MVO) after primary ST-segment elevation acute myocardial infarction (STEMI) is associated with a poor outcome. The aim of the paper was to examine the relationship between distinct monocyte subsets and gadolinium-enhanced cardiovascular magnetic resonance (CMR) characteristics of MVO after STEMI.
METHODS AND RESULTS: Seventy-one patients with primary STEMI successfully treated with stenting were enrolled in the study. Two monocyte subsets (CD14(+)CD16(-) and CD14(+)CD16(+)) were measured on flow cytometry on admission and 2, 3, 4, 5, 8 days after the onset of STEMI. CMR was performed 7 days after revascularization to determine MVO on late gadolinium-enhanced imaging. The peak levels of CD14(+)CD16(-) monocytes, but not those of CD14(+)CD16(+) monocytes, were significantly higher in patients with MVO than in those without MVO. A multivariate logistic regression model showed that the post-perfusion peak levels of CD14(+)CD16(-) monocytes remained an independent factor for the presence of MVO (odds ratio=1.53; 95% confidence interval: 1.01-2.32; P=0.04). The absence of MVO was significantly associated with improvement in left ventricular ejection fraction.
CONCLUSIONS: Post-reperfusion enhancement of CD14(+)CD16(-) monocytes was associated with MVO in patients with STEMI. The pathophysiologic and therapeutic implications of this association require further study.
Authors:
Hiroto Tsujioka; Toshio Imanishi; Hideyuki Ikejima; Takashi Tanimoto; Akio Kuroi; Manabu Kashiwagi; Keishi Okochi; Kohei Ishibashi; Kenichi Komukai; Yasushi Ino; Hironori Kitabata; Takashi Akasaka
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-04-27
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  74     ISSN:  1347-4820     ISO Abbreviation:  Circ. J.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-27     Completed Date:  2010-09-07     Revised Date:  2011-02-18    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1175-82     Citation Subset:  IM    
Affiliation:
Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan.
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MeSH Terms
Descriptor/Qualifier:
Aged
Antigens, CD14*
Coronary Thrombosis / diagnosis*
Female
Flow Cytometry
Gadolinium
Humans
Magnetic Resonance Angiography
Male
Microcirculation*
Middle Aged
Monocytes / pathology*
Myocardial Infarction / complications,  pathology*
Receptors, IgG
Reperfusion
Chemical
Reg. No./Substance:
0/Antigens, CD14; 0/Receptors, IgG; 7440-54-2/Gadolinium

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