| Post-reperfusion enhancement of CD14(+)CD16(-) monocytes and microvascular obstruction in ST-segment elevation acute myocardial infarction. | |
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MedLine Citation:
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PMID: 20453385 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The presence of microvascular obstruction (MVO) after primary ST-segment elevation acute myocardial infarction (STEMI) is associated with a poor outcome. The aim of the paper was to examine the relationship between distinct monocyte subsets and gadolinium-enhanced cardiovascular magnetic resonance (CMR) characteristics of MVO after STEMI. METHODS AND RESULTS: Seventy-one patients with primary STEMI successfully treated with stenting were enrolled in the study. Two monocyte subsets (CD14(+)CD16(-) and CD14(+)CD16(+)) were measured on flow cytometry on admission and 2, 3, 4, 5, 8 days after the onset of STEMI. CMR was performed 7 days after revascularization to determine MVO on late gadolinium-enhanced imaging. The peak levels of CD14(+)CD16(-) monocytes, but not those of CD14(+)CD16(+) monocytes, were significantly higher in patients with MVO than in those without MVO. A multivariate logistic regression model showed that the post-perfusion peak levels of CD14(+)CD16(-) monocytes remained an independent factor for the presence of MVO (odds ratio=1.53; 95% confidence interval: 1.01-2.32; P=0.04). The absence of MVO was significantly associated with improvement in left ventricular ejection fraction. CONCLUSIONS: Post-reperfusion enhancement of CD14(+)CD16(-) monocytes was associated with MVO in patients with STEMI. The pathophysiologic and therapeutic implications of this association require further study. |
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Authors:
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Hiroto Tsujioka; Toshio Imanishi; Hideyuki Ikejima; Takashi Tanimoto; Akio Kuroi; Manabu Kashiwagi; Keishi Okochi; Kohei Ishibashi; Kenichi Komukai; Yasushi Ino; Hironori Kitabata; Takashi Akasaka |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-04-27 |
Journal Detail:
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Title: Circulation journal : official journal of the Japanese Circulation Society Volume: 74 ISSN: 1347-4820 ISO Abbreviation: Circ. J. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-27 Completed Date: 2010-09-07 Revised Date: 2011-02-18 |
Medline Journal Info:
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Nlm Unique ID: 101137683 Medline TA: Circ J Country: Japan |
Other Details:
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Languages: eng Pagination: 1175-82 Citation Subset: IM |
Affiliation:
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Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Antigens, CD14* Coronary Thrombosis / diagnosis* Female Flow Cytometry Gadolinium Humans Magnetic Resonance Angiography Male Microcirculation* Middle Aged Monocytes / pathology* Myocardial Infarction / complications, pathology* Receptors, IgG Reperfusion |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD14; 0/Receptors, IgG; 7440-54-2/Gadolinium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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