| Post-Chernobyl increased prevalence of humoral thyroid autoimmunity in children and adolescents from a moderately iodine-deficient area in Russia. | |
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MedLine Citation:
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PMID: 10482370 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Circulating thyroglobulin antibodies (TgAb) and thyroperoxidase antibodies (TPOAb) were measured in 143 iodine-deficient children, 5 to 15 years of age, from the Region of Tula, Russia, who had been moderately contaminated after the Chernobyl disaster (37-185 GBq/km2 of caesium-137, [group A]) and in 40 sex- and age-matched subjects from an uncontaminated neighboring area (<3.7 GBq/km2 of caesium-137, [group B]). Increased thyroid size at sonography was found in 41% and in 45% subjects from group A and group B, respectively, associated with supranormal thyrotropin (TSH) values in 7.7% of group A and 7.5% of group B, without differences in average serum free thyroxine (FT4), free triiodothyronine (FT3) and TSH. Serum thyroperoxidase antibody (TPOAb)-associated or not with thyroglobulin-antibody (TgAb) as detected in 18.9% of children and adolescents from group A, about four-fold higher than in group B (5%, Fischer's exact test p<0.05). A 24% frequency was found in subjects whose age, at the moment of the disaster was 0-72 months or were in utero, but the frequency was about 7%, similar to that in group B, in those who had not yet been conceived at that time. Less than half of antibody-positive group A children were hyperthyrotropinemic, whereas no group B subclinical hypothyroid subject was antibody-positive, thus excluding the autoimmune etiology of the subclinical thyroid failure; more likely it is attributable to iodine malnutrition. The high prevalence of humoral thyroid autoimmunity phenomena in the investigated area suggests a combined role of iodine malnutrition in enhancing the effects of short lived iodine isotopes, particularly evident in pubertal individuals conceived or born immediately before the Chernobyl disaster. |
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Authors:
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F Vermiglio; M G Castagna; E Volnova; V P Lo Presti; M Moleti; M A Violi; A Artemisia; F Trimarchi |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Thyroid : official journal of the American Thyroid Association Volume: 9 ISSN: 1050-7256 ISO Abbreviation: Thyroid Publication Date: 1999 Aug |
Date Detail:
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Created Date: 1999-10-19 Completed Date: 1999-10-19 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9104317 Medline TA: Thyroid Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 781-6 Citation Subset: IM |
Affiliation:
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Cattedra di Endocrinologia, University of Messina, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Age Factors Autoantibodies / immunology Child Child, Preschool Female Goiter / epidemiology, immunology Humans Immunoglobulins, Thyroid-Stimulating Iodide Peroxidase / immunology Iodine / deficiency* Male Radioactive Hazard Release* Russia / epidemiology Thyroglobulin / immunology Thyroid Function Tests Thyroiditis, Autoimmune / epidemiology* Ukraine |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies; 0/Immunoglobulins, Thyroid-Stimulating; 7553-56-2/Iodine; 9010-34-8/Thyroglobulin; EC 1.11.1.8/Iodide Peroxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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