Document Detail

Post-Chernobyl increased prevalence of humoral thyroid autoimmunity in children and adolescents from a moderately iodine-deficient area in Russia.
MedLine Citation:
PMID:  10482370     Owner:  NLM     Status:  MEDLINE    
Circulating thyroglobulin antibodies (TgAb) and thyroperoxidase antibodies (TPOAb) were measured in 143 iodine-deficient children, 5 to 15 years of age, from the Region of Tula, Russia, who had been moderately contaminated after the Chernobyl disaster (37-185 GBq/km2 of caesium-137, [group A]) and in 40 sex- and age-matched subjects from an uncontaminated neighboring area (<3.7 GBq/km2 of caesium-137, [group B]). Increased thyroid size at sonography was found in 41% and in 45% subjects from group A and group B, respectively, associated with supranormal thyrotropin (TSH) values in 7.7% of group A and 7.5% of group B, without differences in average serum free thyroxine (FT4), free triiodothyronine (FT3) and TSH. Serum thyroperoxidase antibody (TPOAb)-associated or not with thyroglobulin-antibody (TgAb) as detected in 18.9% of children and adolescents from group A, about four-fold higher than in group B (5%, Fischer's exact test p<0.05). A 24% frequency was found in subjects whose age, at the moment of the disaster was 0-72 months or were in utero, but the frequency was about 7%, similar to that in group B, in those who had not yet been conceived at that time. Less than half of antibody-positive group A children were hyperthyrotropinemic, whereas no group B subclinical hypothyroid subject was antibody-positive, thus excluding the autoimmune etiology of the subclinical thyroid failure; more likely it is attributable to iodine malnutrition. The high prevalence of humoral thyroid autoimmunity phenomena in the investigated area suggests a combined role of iodine malnutrition in enhancing the effects of short lived iodine isotopes, particularly evident in pubertal individuals conceived or born immediately before the Chernobyl disaster.
F Vermiglio; M G Castagna; E Volnova; V P Lo Presti; M Moleti; M A Violi; A Artemisia; F Trimarchi
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Thyroid : official journal of the American Thyroid Association     Volume:  9     ISSN:  1050-7256     ISO Abbreviation:  Thyroid     Publication Date:  1999 Aug 
Date Detail:
Created Date:  1999-10-19     Completed Date:  1999-10-19     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9104317     Medline TA:  Thyroid     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  781-6     Citation Subset:  IM    
Cattedra di Endocrinologia, University of Messina, Italy.
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MeSH Terms
Age Factors
Autoantibodies / immunology
Child, Preschool
Goiter / epidemiology,  immunology
Immunoglobulins, Thyroid-Stimulating
Iodide Peroxidase / immunology
Iodine / deficiency*
Radioactive Hazard Release*
Russia / epidemiology
Thyroglobulin / immunology
Thyroid Function Tests
Thyroiditis, Autoimmune / epidemiology*
Reg. No./Substance:
0/Autoantibodies; 0/Immunoglobulins, Thyroid-Stimulating; 7553-56-2/Iodine; 9010-34-8/Thyroglobulin; EC Peroxidase

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