Document Detail

Possibly enhanced Gd excretion in dialysate, but no major clinical benefit of 3-5 months of treatment with sodium thiosulfate in late stages of nephrogenic systemic fibrosis.
MedLine Citation:
PMID:  18436563     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Gd-related nephrogenic systemic fibrosis was successfully treated with intravenous sodium thiosulfate according to a recent case report. METHODS: Four haemodialysis patients with severe Gd-related nephrogenic systemic fibrosis were treated with intravenous sodium thiosulfate for 3-5 months. Symptoms and patients' experiences were investigated. The dialysate Gd content was monitored. RESULTS: We observed no major clinical improvements in any patient. In one patient, we found slightly improved joint motion. Two patients had a subjective impression of slight improvements of joint motion and skin abnormalities. The dialysate Gd content was raised by the treatment, up to fivefold. CONCLUSIONS: We could not confirm that sodium thiosulfate treatment results in marked and rapid improvement in late stages of Gd-related nephrogenic systemic fibrosis. However, dialysate contents of Gd seemed to increase. It is unknown whether increased Gd excretion will lead to long-term clinical improvements in late stages of nephrogenic systemic fibrosis.
Peter Marckmann; Arne Høj Nielsen; Jens Jørgen Sloth
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2008-04-24
Journal Detail:
Title:  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association     Volume:  23     ISSN:  1460-2385     ISO Abbreviation:  Nephrol. Dial. Transplant.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-09-18     Completed Date:  2009-02-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8706402     Medline TA:  Nephrol Dial Transplant     Country:  England    
Other Details:
Languages:  eng     Pagination:  3280-2     Citation Subset:  IM    
Department of nephrology, Copenhagen University Hospital Herlev, Herlev Ringvej 75, DK-2730 Herlev, Denmark.
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MeSH Terms
Chelating Agents / therapeutic use
Contrast Media / adverse effects,  pharmacokinetics
Gadolinium / adverse effects*,  pharmacokinetics*
Gadolinium DTPA / adverse effects,  pharmacokinetics
Hemodialysis Solutions / analysis
Magnetic Resonance Imaging / adverse effects
Middle Aged
Nephrogenic Fibrosing Dermopathy / drug therapy*,  etiology*,  metabolism,  prevention & control
Renal Dialysis
Renal Insufficiency / diagnosis
Thiosulfates / therapeutic use*
Time Factors
Reg. No./Substance:
0/Chelating Agents; 0/Contrast Media; 0/Hemodialysis Solutions; 0/Thiosulfates; 122795-43-1/gadodiamide; 7440-54-2/Gadolinium; 7772-98-7/sodium thiosulfate; 80529-93-7/Gadolinium DTPA

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