| Possibly enhanced Gd excretion in dialysate, but no major clinical benefit of 3-5 months of treatment with sodium thiosulfate in late stages of nephrogenic systemic fibrosis. | |
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MedLine Citation:
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PMID: 18436563 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Gd-related nephrogenic systemic fibrosis was successfully treated with intravenous sodium thiosulfate according to a recent case report. METHODS: Four haemodialysis patients with severe Gd-related nephrogenic systemic fibrosis were treated with intravenous sodium thiosulfate for 3-5 months. Symptoms and patients' experiences were investigated. The dialysate Gd content was monitored. RESULTS: We observed no major clinical improvements in any patient. In one patient, we found slightly improved joint motion. Two patients had a subjective impression of slight improvements of joint motion and skin abnormalities. The dialysate Gd content was raised by the treatment, up to fivefold. CONCLUSIONS: We could not confirm that sodium thiosulfate treatment results in marked and rapid improvement in late stages of Gd-related nephrogenic systemic fibrosis. However, dialysate contents of Gd seemed to increase. It is unknown whether increased Gd excretion will lead to long-term clinical improvements in late stages of nephrogenic systemic fibrosis. |
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Authors:
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Peter Marckmann; Arne Høj Nielsen; Jens Jørgen Sloth |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2008-04-24 |
Journal Detail:
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Title: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association Volume: 23 ISSN: 1460-2385 ISO Abbreviation: Nephrol. Dial. Transplant. Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-09-18 Completed Date: 2009-02-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8706402 Medline TA: Nephrol Dial Transplant Country: England |
Other Details:
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Languages: eng Pagination: 3280-2 Citation Subset: IM |
Affiliation:
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Department of nephrology, Copenhagen University Hospital Herlev, Herlev Ringvej 75, DK-2730 Herlev, Denmark. peter.marckmann@dadlnet.dk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Chelating Agents / therapeutic use Contrast Media / adverse effects, pharmacokinetics Female Gadolinium / adverse effects*, pharmacokinetics* Gadolinium DTPA / adverse effects, pharmacokinetics Hemodialysis Solutions / analysis Humans Magnetic Resonance Imaging / adverse effects Middle Aged Nephrogenic Fibrosing Dermopathy / drug therapy*, etiology*, metabolism, prevention & control Renal Dialysis Renal Insufficiency / diagnosis Thiosulfates / therapeutic use* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Chelating Agents; 0/Contrast Media; 0/Hemodialysis Solutions; 0/Thiosulfates; 122795-43-1/gadodiamide; 7440-54-2/Gadolinium; 7772-98-7/sodium thiosulfate; 80529-93-7/Gadolinium DTPA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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