Document Detail

Possible two-stage transplacental liver carcinogenesis in C57BL/6 mice.
MedLine Citation:
PMID:  197029     Owner:  NLM     Status:  MEDLINE    
A single SC injection of 2-acetylaminofluorene (AAF) was given to pregnant C57BL/6 mice on day 15 of gestation, and the offspring subsequently given twice-weekly injections of phorbol for 25 weeks. Control groups included: (1) untreated; (2) AAF-treated mothers (kept under observation for 18 months, as with all the other groups); (3) untreated offspring of untreated mothers; (4) untreated offspring of AAF-treated mothers, and (5) phorbol-treated offspring of untreated mothers. The incidence of hepatomas in the phorbol-treated offspring of AAF-injected mothers was 8/74 (11%), as compared with 2/80 (2.5%) in the untreated offspring of AAF-injected mothers. The AAF-injected mothers themselves developed 3/36 (8%) hepatomas; while all othe other control groups were free from liver tumours. The development of reticulum cell sarcomas, and of a few cases of lung adenomas, in the various groups, was presumably spontaneous. The results seem sufficiently encouraging, as a model for the study of systemic carcinogenesis, to warrant further attempts at two-stage transplacental carcinogenesis, using other potential initiators and promoters.
V Armuth; I Berenblum
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of cancer. Journal international du cancer     Volume:  20     ISSN:  0020-7136     ISO Abbreviation:  Int. J. Cancer     Publication Date:  1977 Aug 
Date Detail:
Created Date:  1977-10-28     Completed Date:  1977-10-28     Revised Date:  2007-07-24    
Medline Journal Info:
Nlm Unique ID:  0042124     Medline TA:  Int J Cancer     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  292-5     Citation Subset:  IM    
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MeSH Terms
2-Acetylaminofluorene* / metabolism
Carcinoma, Hepatocellular / chemically induced*
Fluorenes* / metabolism
Liver Neoplasms / chemically induced*
Maternal-Fetal Exchange*
Mice, Inbred C57BL
Phorbols* / metabolism
Reg. No./Substance:
0/Fluorenes; 0/Phorbols; 53-96-3/2-Acetylaminofluorene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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