Document Detail

Possible tubular site of action in anesthetized dogs of a synthetic alpha-human atrial natriuretic polypeptide.
MedLine Citation:
PMID:  2942679     Owner:  NLM     Status:  MEDLINE    
Intrarenal arterial infusion of a synthetic alpha-human atrial natriuretic polypeptide (alpha-hANP) in a dose of 5.0 micrograms/min to anesthetized dogs led to a significant increase in urine flow and urinary excretion of electrolytes. Tubular sites of action of alpha-hANP were determined by using free water clearance techniques and in stop-flow experiments. During water diuresis, free water clearance did not increase in proportion to the increase in urine flow rate. Intrarenal administration of the peptide to dehydrated animals resulted in no change in solute-free water reabsorption, notwithstanding a significant increase in osmolar clearance. These data suggest that the peptide acts on the diluting segment of the ascending limb of Henle and also at the distal nephrons, findings which support data obtained in stop-flow experiments. Infusion of the peptide lowered inulin concentration and elevated sodium concentration in the stop-flow urine from the distal tubules and collecting duct. It is tentatively concluded that alpha-hANP produces potent diuretic and natriuretic responses by suppressing water and sodium transport in the distal portion of the nephron.
T Yukimura; K Ito; T Takenaga; K Yamamoto; K Kangawa; H Matsuo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of pharmacology and experimental therapeutics     Volume:  238     ISSN:  0022-3565     ISO Abbreviation:  J. Pharmacol. Exp. Ther.     Publication Date:  1986 Aug 
Date Detail:
Created Date:  1986-09-17     Completed Date:  1986-09-17     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0376362     Medline TA:  J Pharmacol Exp Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  707-12     Citation Subset:  IM    
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MeSH Terms
Atrial Natriuretic Factor / pharmacology*
Blood Pressure / drug effects
Diuresis / drug effects
Electrolytes / urine
Furosemide / pharmacology
Kidney Tubules / drug effects*,  metabolism
Renal Circulation / drug effects
Reg. No./Substance:
0/Electrolytes; 54-31-9/Furosemide; 85637-73-6/Atrial Natriuretic Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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