Document Detail


Possible strategies to protect the preterm brain against the fetal inflammatory response.
MedLine Citation:
PMID:  11268718     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The accruing evidence that a fetal inflammatory response is the link between antenatal infection and white matter damage in the preterm newborn infant offers room for speculation how this harmful sequence could be interrupted. Enhancement of endogenous protection, response modification, and damage limitation downstream could be helpful strategies for intervention design. Appropriate observational and experimental studies are needed before clinical interventions can be initiated.
Authors:
O Dammann; A Leviton
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Developmental medicine and child neurology. Supplement     Volume:  86     ISSN:  0419-0238     ISO Abbreviation:  Dev Med Child Neurol Suppl     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2001-03-27     Completed Date:  2001-08-09     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0006762     Medline TA:  Dev Med Child Neurol Suppl     Country:  England    
Other Details:
Languages:  eng     Pagination:  18-20     Citation Subset:  IM    
Affiliation:
Neuroepidemiology Unit, Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA.
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MeSH Terms
Descriptor/Qualifier:
Antibodies / immunology
Blood-Brain Barrier / physiology
Brain / embryology*,  immunology,  metabolism
Cytokines / immunology
Fetal Diseases / immunology,  prevention & control*
Humans
Infant, Newborn
Infant, Premature, Diseases / immunology,  prevention & control*
Infant, Small for Gestational Age
Infant, Very Low Birth Weight
Inflammation / embryology*,  immunology,  prevention & control*
Intercellular Adhesion Molecule-1 / metabolism
Matrix Metalloproteinase 9 / metabolism
Receptors, Cytokine / antagonists & inhibitors
Chemical
Reg. No./Substance:
0/Antibodies; 0/Cytokines; 0/Receptors, Cytokine; 126547-89-5/Intercellular Adhesion Molecule-1; EC 3.4.24.35/Matrix Metalloproteinase 9

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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