Document Detail

Possible selection of virulent poliovirus strains in Third-World countries.
MedLine Citation:
PMID:  54685     Owner:  NLM     Status:  MEDLINE    
In Kenya for more than twenty years a remarkable periodicity has been observed in the circulation of type-1 poliovirus and in epidemics of poliomyelitis caused by this virus type. Periodicity was less obvious for poliovirus types 2 and 3. Cases of poliomyelitis increased, and this trend was only partly controlled by vaccination. It is postulated that virulent strains of poliovirus became dominant because of selection pressure. It is suggested that this selection pressure occurred earlier in economically developed countries and was partly responsible for the pronounced changes in the epidemiology of poliomyelitis seen in such countries.
D Metselaar
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Lancet     Volume:  1     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1976 Jan 
Date Detail:
Created Date:  1976-03-30     Completed Date:  1976-03-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  174-6     Citation Subset:  AIM; IM    
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MeSH Terms
Age Factors
Child, Preschool
Continental Population Groups
Disease Outbreaks
Poliomyelitis / epidemiology,  microbiology*
Poliovirus / isolation & purification,  pathogenicity*
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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