Document Detail

Possible roles of bilirubin and breast milk in protection against retinopathy of prematurity.
MedLine Citation:
PMID:  20969622     Owner:  NLM     Status:  MEDLINE    
AIM: To explore the association of serum bilirubin level and breast milk feeding with retinopathy of prematurity (ROP) in preterm infants.
METHODS: We conducted a case-control study to examine the independent and combined effects of serum bilirubin and breast milk feeding on ROP risk in infants <32 weeks gestation or with birth weight <1500 g. Cases (66 infants with ROP) were matched with controls (66 infants without ROP) based on factors known to affect ROP risk.
RESULTS: When analysed using the paired t-test, the peak bilirubin levels were lower in ROP cases than in controls (mean 7.2 vs. 7.9 mg/dL; p = 0.045). Using conditional logistic regression, we found a negative association between highest serum bilirubin level and risk of ROP (OR = 0.82 per 1-mg/dL change in bilirubin; p = 0.06). There was no significant association between breast milk feeding and risk of ROP.
CONCLUSION: Bilirubin may help to protect preterm infants against ROP.
Joanna S Kao; Jeffrey D Dawson; Jeffrey C Murray; John M Dagle; Susan K Berends; Susan B Gillen; Edward F Bell
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-11-05
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  100     ISSN:  1651-2227     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-01     Completed Date:  2011-06-16     Revised Date:  2014-07-29    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  347-51     Citation Subset:  IM    
Copyright Information:
© 2010 The Author(s)/Acta Paediatrica © 2010 Foundation Acta Paediatrica.
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MeSH Terms
Bilirubin / blood*
Breast Feeding*
Case-Control Studies
Gestational Age
Infant, Newborn
Infant, Premature
Infant, Very Low Birth Weight
Milk, Human*
Retinopathy of Prematurity / blood,  prevention & control*
Retrospective Studies
Risk Factors
Grant Support
M01 RR000059/RR/NCRR NIH HHS; M01 RR000059-46/RR/NCRR NIH HHS; R01 HD052953/HD/NICHD NIH HHS; R01 HD052953/HD/NICHD NIH HHS; R01 HD052953-05/HD/NICHD NIH HHS; R01 HD057192-03/HD/NICHD NIH HHS; UL1 RR024979/RR/NCRR NIH HHS; UL1 RR024979-05/RR/NCRR NIH HHS
Reg. No./Substance:

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