Document Detail


Possible role of prostaglandins as negative regulators in growth stimulation by tumor necrosis factor and epidermal growth factor in human fibroblasts.
MedLine Citation:
PMID:  2808538     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recombinant tumor necrosis factor (TNF), epidermal growth factor (EGF), and transforming growth factor beta (TGF-beta) stimulated growth of confluent human diploid fibroblasts (FS-4 cells) in the presence of fetal calf serum. TGF-beta synergistically enhanced both the TNF- and EGF-stimulated cell growth, whereas synergism between the mitogenic action of EGF and that of TNF was not observed. When indomethacin or acetylsalicylic acid, an inhibitor of prostaglandin production, was added to FS-4 cells, cell growth stimulated by EGF or TNF was increased, suggesting that prostaglandins induced by these mitogens antagonize their growth stimulatory actions. In contrast, neither indomethacin nor acetylsalicylic acid had a significant effect on the TGF-beta-induced growth of FS-4 cells. Mitogenic responses of indomethacin-treated cells to EGF, TNF, and TGF-beta were similarly suppressed by the addition of exogenous prostaglandin D2 (PGD2). Other prostaglandins such as PGE2 and PGF2 produced less inhibition of the cell growth.
Authors:
T Hori; S Kashiyama; M Hayakawa; S Shibamoto; M Tsujimoto; N Oku; F Ito
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cellular physiology     Volume:  141     ISSN:  0021-9541     ISO Abbreviation:  J. Cell. Physiol.     Publication Date:  1989 Nov 
Date Detail:
Created Date:  1989-12-01     Completed Date:  1989-12-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0050222     Medline TA:  J Cell Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  275-80     Citation Subset:  IM    
Affiliation:
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Setsunan University, Osaka, Japan.
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MeSH Terms
Descriptor/Qualifier:
Arachidonic Acids / metabolism
Aspirin / pharmacology
Cell Division / drug effects
Cell Line
Cells, Cultured
Child, Preschool
Epidermal Growth Factor / pharmacology*
Fibroblasts / cytology*,  drug effects
Humans
Indomethacin / pharmacology
Prostaglandins / pharmacology,  physiology*
Tumor Necrosis Factor-alpha / pharmacology*
Chemical
Reg. No./Substance:
0/Arachidonic Acids; 0/Prostaglandins; 0/Tumor Necrosis Factor-alpha; 50-78-2/Aspirin; 53-86-1/Indomethacin; 62229-50-9/Epidermal Growth Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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