Document Detail

Possible role of prostaglandins as negative regulators in growth stimulation by tumor necrosis factor and epidermal growth factor in human fibroblasts.
MedLine Citation:
PMID:  2808538     Owner:  NLM     Status:  MEDLINE    
Recombinant tumor necrosis factor (TNF), epidermal growth factor (EGF), and transforming growth factor beta (TGF-beta) stimulated growth of confluent human diploid fibroblasts (FS-4 cells) in the presence of fetal calf serum. TGF-beta synergistically enhanced both the TNF- and EGF-stimulated cell growth, whereas synergism between the mitogenic action of EGF and that of TNF was not observed. When indomethacin or acetylsalicylic acid, an inhibitor of prostaglandin production, was added to FS-4 cells, cell growth stimulated by EGF or TNF was increased, suggesting that prostaglandins induced by these mitogens antagonize their growth stimulatory actions. In contrast, neither indomethacin nor acetylsalicylic acid had a significant effect on the TGF-beta-induced growth of FS-4 cells. Mitogenic responses of indomethacin-treated cells to EGF, TNF, and TGF-beta were similarly suppressed by the addition of exogenous prostaglandin D2 (PGD2). Other prostaglandins such as PGE2 and PGF2 produced less inhibition of the cell growth.
T Hori; S Kashiyama; M Hayakawa; S Shibamoto; M Tsujimoto; N Oku; F Ito
Related Documents :
3277938 - Liver epithelial cell migration induced by epidermal growth factor or transforming grow...
17466298 - Expression of adiponectin in choroidal tissue and inhibition of laser induced choroidal...
24857698 - Thyroid hormones and fear learning but not anxiety are affected in adult apoe transgeni...
6334278 - Effects of epidermal growth factor on deoxyribonucleic acid synthesis and stomach weigh...
8826968 - Control of islet intercellular adhesion molecule-1 expression by interferon-alpha and h...
8872638 - Modified control of breathing in genetically obese (ob/ob) mice.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cellular physiology     Volume:  141     ISSN:  0021-9541     ISO Abbreviation:  J. Cell. Physiol.     Publication Date:  1989 Nov 
Date Detail:
Created Date:  1989-12-01     Completed Date:  1989-12-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0050222     Medline TA:  J Cell Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  275-80     Citation Subset:  IM    
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Setsunan University, Osaka, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Arachidonic Acids / metabolism
Aspirin / pharmacology
Cell Division / drug effects
Cell Line
Cells, Cultured
Child, Preschool
Epidermal Growth Factor / pharmacology*
Fibroblasts / cytology*,  drug effects
Indomethacin / pharmacology
Prostaglandins / pharmacology,  physiology*
Tumor Necrosis Factor-alpha / pharmacology*
Reg. No./Substance:
0/Arachidonic Acids; 0/Prostaglandins; 0/Tumor Necrosis Factor-alpha; 50-78-2/Aspirin; 53-86-1/Indomethacin; 62229-50-9/Epidermal Growth Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Extracellular matrix: differential influence on growth and biosynthesis patterns of vascular smooth ...
Next Document:  Enucleation of the rat pheochromocytoma clonal cell line, PC12: effect on neurite outgrowth.