Document Detail

Possible role of oxygen-derived, free radicals in cardiocirculatory shock.
MedLine Citation:
PMID:  2821638     Owner:  NLM     Status:  MEDLINE    
The release of oxygen free radicals from ischemic myocardial tissue has been implicated as a causative factor of cell membrane damage and cardiac dysfunction in hemorrhagic shock. This study was done to determine whether or not hydrogen peroxide (H2O2) and superoxide ion (O2) are responsible for cardiac injury from hemorrhagic shock as indicated by reduced coronary perfusion and impaired contractile function. This hypothesis was tested by infusing selective O2 and H2O2 scavengers into anesthetized dogs in a state of shock, either during shock (group 3) or with fluid resuscitation (group 2) and comparing the cardiovascular response to that seen with shock and fluid resuscitation alone (group 1). We found no significant difference in shock induced derangements in myocardial oxygen metabolism or the degree of myocardial depression and regional ischemia in dogs in a state of shock given superoxide dismutase plus catalase, compared with shock alone. The results of our data suggested that, if O2 and H2O2 play a causative role in shock induced cardiac dysfunction or during reperfusion after shock, free radical scavengers must be administered early in the ischemic period. Furthermore, free radical scavengers administered with reperfusion do not enchance cardiac function nor myocardial perfusion.
J W Horton; K R Borman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Surgery, gynecology & obstetrics     Volume:  165     ISSN:  0039-6087     ISO Abbreviation:  Surg Gynecol Obstet     Publication Date:  1987 Oct 
Date Detail:
Created Date:  1987-11-02     Completed Date:  1987-11-02     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0101370     Medline TA:  Surg Gynecol Obstet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  293-300     Citation Subset:  AIM; IM    
University of Texas Health Science Center, Department of Surgery, Dallas 75235-9031.
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MeSH Terms
Catalase / therapeutic use*
Coronary Circulation
Fluid Therapy
Free Radicals
Hydrogen Peroxide*
Myocardial Contraction
Myocardium / metabolism
Oxygen Consumption
Shock, Hemorrhagic / etiology*,  therapy
Superoxide Dismutase / therapeutic use*
Reg. No./Substance:
0/Free Radicals; 11062-77-4/Superoxides; 7722-84-1/Hydrogen Peroxide; EC; EC Dismutase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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