| Possible role of hypercoagulability in calciphylaxis: Review of the literature. | |
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MedLine Citation:
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PMID: 20708299 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: The role of a hypercoagulable state in the pathogenesis of calciphylaxis has yet to be determined. OBJECTIVE: We sought to find evidence of an association between hypercoagulability and calciphylaxis. METHODS: We reviewed the primary literature for review articles, studies, and case reports that discussed or demonstrated a possible relationship between calciphylaxis and a hypercoagulable state. RESULTS: Review of the primary literature showed that in cases of calciphylaxis with reported levels of protein C and S, 38% of the patients had decreased protein C levels and 43% had decreased levels of protein S. From review of case reports, 3 cases of improvement of skin lesions with low molecular weight heparin treatment, and a fourth case of healing of skin lesions with tissue plasminogen activator treatment, were found. Calciphylaxis was also found in a patient with antiphospholipid antibody syndrome, and a patient with cryofibrinogenemia had clinical and histologic findings consistent with possible calciphylaxis. LIMITATIONS: A limited number of reports were available for review. CONCLUSION: Our review of the literature found sufficient evidence to suggest a possible role of a hypercoagulable state in the pathogenesis of calciphylaxis. A prospective study with serial testing of all relevant clotting factors in patients with calciphylaxis is needed to more definitively establish this role. |
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Authors:
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Ryan Jeffrey Harris; Thomas George Cropley |
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Publication Detail:
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Type: Journal Article Date: 2010-08-12 |
Journal Detail:
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Title: Journal of the American Academy of Dermatology Volume: 64 ISSN: 1097-6787 ISO Abbreviation: J. Am. Acad. Dermatol. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7907132 Medline TA: J Am Acad Dermatol Country: United States |
Other Details:
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Languages: eng Pagination: 405-12 Citation Subset: IM |
Copyright Information:
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Copyright © 2009 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved. |
Affiliation:
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School of Medicine, University of Virginia, Charlottesville, Virginia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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