| Possible role of apoptotic cells of the oral epithelium in the pathogenesis of aphthous ulceration. | |
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MedLine Citation:
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PMID: 3858774 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Electron microscopic examination of the normal oral mucosa of patients with recurrent aphthous ulceration or Behçet's syndrome revealed that the degenerate dark prickle cells are apoptotic cells. Such dark prickle cells showed characteristic findings of apoptosis, such as the shrinkage of nucleus and cytoplasm and the formation of contraction vacuoles. The number of intraepithelial mononuclear cells phagocytosing apoptotic cellular debris increased remarkably at the preulcerative stage of the aphthous lesions. The apoptotic debris also attracted neutrophilic leukocytes in the prickle cell layer at the preulcerative stage but not in the normal oral epithelium. It is speculated that the onset of aphthous ulceration is closely related to phagocytosis of these apoptotic cells by intraepithelial mononuclear cells. |
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Authors:
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T Honma; T Saito; Y Fujioka |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Oral surgery, oral medicine, and oral pathology Volume: 59 ISSN: 0030-4220 ISO Abbreviation: Oral Surg. Oral Med. Oral Pathol. Publication Date: 1985 Apr |
Date Detail:
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Created Date: 1985-07-03 Completed Date: 1985-07-03 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0376406 Medline TA: Oral Surg Oral Med Oral Pathol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 379-87 Citation Subset: D; IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Behcet Syndrome
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etiology*,
pathology Cell Nucleus / ultrastructure Epithelial Cells Epithelium / ultrastructure Gingiva / cytology, ultrastructure Humans Leukocytes / cytology, ultrastructure Microscopy, Electron Mouth Mucosa / cytology*, ultrastructure Organoids / ultrastructure Phagocytes / cytology, ultrastructure Stomatitis, Aphthous / etiology*, pathology |
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