Document Detail

Possible relationship between low birth weight and magnesium status: from the standpoint of "fetal origin" hypothesis.
MedLine Citation:
PMID:  16846102     Owner:  NLM     Status:  MEDLINE    
Magnesium deficiency in pregnant women is frequently seen because of inadequate or low intake of magnesium. Magnesium deficiency during pregnancy can induce not only maternal and fetal nutritional problems, but also consequences that might last in offspring throughout life. Many epidemiological studies have shown that restricted fetal growth, i.e. intrauterine growth retardation (IUGR), is associated with an increased risk of insulin resistance in adult life. We previously postulated that the intracellular magnesium of cord blood platelets is lower in the small for gestational age group than in the appropriate for gestational age group, suggesting that intrauterine magnesium deficiency may result in IUGR. Taken together, intrauterine magnesium deficiency in the fetus may lead to or program the insulin resistance after birth. We hypothesize that intrauterine magnesium deficiency may induce a metabolic syndrome in later life. Prospective studies will further clarify whether infants with IUGR induced by magnesium deficiency are at higher risk for metabolic syndromes in childhood or adulthood.
J Takaya; F Yamato; K Kaneko
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Magnesium research : official organ of the International Society for the Development of Research on Magnesium     Volume:  19     ISSN:  0953-1424     ISO Abbreviation:  Magnes Res     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-07-18     Completed Date:  2007-01-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8900948     Medline TA:  Magnes Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  63-9     Citation Subset:  IM    
Department of Pediatrics, Kansai Medical University, Moriguchi, Osaka, Japan.
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MeSH Terms
Dietary Supplements
Fetal Growth Retardation
Fetus / physiology*
Infant, Low Birth Weight*
Infant, Newborn
Magnesium / administration & dosage,  blood*
Magnesium Deficiency*
Placenta / metabolism
Pregnancy Outcome
Reg. No./Substance:

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