| Possible relationship between altered fatty acid composition of serum, platelets, and aorta and hypertension induced by sugar feeding in rats. | |
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MedLine Citation:
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PMID: 10685728 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To establish a relationship between alterations in fatty acid metabolism, induced by sugar ingestion, and hypertension, we analyzed fatty acid composition of serum, platelets and aorta in rats which had 30% of sugar in their drinking water for 18-20 weeks, and became hypertensive, hypertriglyceridemic and hyperinsulinemic. The fatty acid composition in sugar-fed as compared with that from control rats was as follows: in serum phospholipids, triglycerides and cholesterol ester fractions, palmitic, palmitoleic, oleic and cis-11-eicosadecaenoic acids were present in a higher proportion. In serum phospholipid fraction linoleic and arachidonic acids were decreased and a significant increase was observed in the proportion of dihomo-gamma-linolenic acid. In the membrane phospholipids of platelets and aorta, higher proportions of palmitoleic and of oleic acids were observed. Differences in fatty acid composition of phospholipids between sugar-fed and control rats are consistent with altered membrane fluidity. Altered membrane function is a potential mechanism involved hypertension in rats in sugar-induced. |
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Authors:
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M El Hafidi; R Valdez; G Baños |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical and experimental hypertension (New York, N.Y. : 1993) Volume: 22 ISSN: 1064-1963 ISO Abbreviation: Clin. Exp. Hypertens. Publication Date: 2000 Jan |
Date Detail:
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Created Date: 2000-03-15 Completed Date: 2000-03-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9305929 Medline TA: Clin Exp Hypertens Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 99-108 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, Instituto Nacional de Cardiología Ignacio Chávez, México. elhafidi@cenids.ssa.gob.mx |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aorta, Thoracic / metabolism* Biological Markers Blood Platelets / metabolism* Blood Pressure Carbohydrates / toxicity* Cell Membrane / metabolism Cholesterol Esters / metabolism Disease Models, Animal Fatty Acids / blood* Hypertension / chemically induced, metabolism* Male Phospholipids / metabolism Rats Rats, Wistar Triglycerides / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Carbohydrates; 0/Cholesterol Esters; 0/Fatty Acids; 0/Phospholipids; 0/Triglycerides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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