| Possible predictors of target lesion revascularization after drug-eluting stent implantation. | |
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MedLine Citation:
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PMID: 17354579 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: A small number of patients still need target lesion revascularization (TLR) after drug-eluting stent (DES) implantation. It is important for the management of coronary artery disease to assess the predictors of TLR after DES implantation. METHODS AND RESULTS: Two hundred ninety-seven patients (325 lesions) were treated with Cypher sirolimus-eluting and/or TAXUS paclitaxel-eluting stent implantation at four centers in Japan and Brazil. Among these centers, 20 patients (24 lesions) needed clinically driven TLR. The clinical and angiographic characteristics of TLR patients were compared to those of non-TLR patients. Hemodialysis, prior myocardial infarction (MI) and prior coronary artery bypass grafting (CABG) were more frequent in TLR patients than in non-TLR patients. An ostial stenosis was more frequent in the TLR group than in the non-TLR group (41.7% vs 19.9%, p=0.012). In addition, post-procedure in-stent percentage diameter stenosis (%DS) was higher in TLR patients (21.9% vs 13.3%, p = 0.002). Stepwise logistic regression analysis indicated that all of these variables were independent predictors of TLR after DES implantation. CONCLUSIONS: Hemodialysis, prior MI, prior CABG, ostial lesion location and high in-stent %DS may be independent predictors of TLR after DES implantation. |
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Authors:
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Daizaburo Yanagi; Kazuyuki Shirai; Ken Mori; Amane Ike; Costantino O Costantini; Costantino R Costantini; Hiroaki Nishikawa; Nathan Miller; Bo Zhang; Yoshihiro Tsuchiya; Hidenori Urata; Keijiro Saku |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of cardiology Volume: 49 ISSN: 0914-5087 ISO Abbreviation: J Cardiol Publication Date: 2007 Feb |
Date Detail:
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Created Date: 2007-03-14 Completed Date: 2007-04-24 Revised Date: 2010-03-24 |
Medline Journal Info:
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Nlm Unique ID: 8804703 Medline TA: J Cardiol Country: Japan |
Other Details:
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Languages: eng Pagination: 63-7 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Fukuoka University School of Medicine, Fukuoka. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Coronary Artery Bypass Coronary Artery Disease / therapy* Coronary Restenosis / epidemiology*, etiology* Female Forecasting Humans Logistic Models Male Middle Aged Myocardial Revascularization* / statistics & numerical data Paclitaxel / administration & dosage* Renal Dialysis Sirolimus / administration & dosage* Stents* / adverse effects |
| Chemical | |
Reg. No./Substance:
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33069-62-4/Paclitaxel; 53123-88-9/Sirolimus |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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