Document Detail

Possible prediction of adverse reactions to fluorouracil by the measurement of urinary dihydrothymine and thymine.
MedLine Citation:
PMID:  9857238     Owner:  NLM     Status:  MEDLINE    
Dihydropyrimidine dehydrogenase (DPD) deficiency with a defect of the pyrimidine catabolic pathway has recently become the focus of considerable attention, due to the severe 5-fluorouracil (5-FU) toxicities occurring in DPD deficiency patients. Studies also suggest that 5-FU toxicities could occur in another pyrimidine metabolic disorder, dihydropyrimidinuria (DHPuria). This study shows that urinary dihydrothymine (DHT) and thymine (THY) are useful indexes for detection of DPD deficiency and DHPuria. We measured urinary DHT and THY in 276 Japanese adults to establish reference ranges. When males and females were compared, both DHT and THY levels were found to be significantly higher in females. The reference ranges (mean +/- SD with logarithmic values) for males were found to be 1.56-5.70 micromol/g of creatinine for DHT and 0.40-1.47 micromol/g of creatinine for THY. The reference ranges for females were found to be 1.89-8.33 micromol/g of creatinine for DHT and 0.58-2.30 micromol/g of creatinine for THY. In addition to this study we analyzed a DPD deficiency case and a DHPuria case. In the DPD deficiency case, the THY concentrations of all urine samples were out of the reference range. However, uracil levels in most of the samples were within the normal range. The DHPuria case excreted large amounts of DHT and dihydrouracil, both out of the normal range.
S Sumi; K Kidouchi; M Kondou; K Hayashi; K Dobashi; M Kouwaki; H Togari; Y Wada
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of molecular medicine     Volume:  2     ISSN:  1107-3756     ISO Abbreviation:  Int. J. Mol. Med.     Publication Date:  1998 Oct 
Date Detail:
Created Date:  2007-12-14     Completed Date:  2008-06-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9810955     Medline TA:  Int J Mol Med     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  477-82     Citation Subset:  IM    
Department of Pediatrics, Nagoya City University Medical School, Nagoya 467-8601, Japan.
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MeSH Terms
Antimetabolites, Antineoplastic / adverse effects*
Child, Preschool
Dihydrouracil Dehydrogenase (NADP) / deficiency
Fluorouracil / adverse effects*
Infant, Newborn
Middle Aged
Predictive Value of Tests
Purine-Pyrimidine Metabolism, Inborn Errors / diagnosis,  urine
Pyrimidines / urine
Reference Values
Thymine / urine*
Reg. No./Substance:
0/Antimetabolites, Antineoplastic; 0/Pyrimidines; 51-21-8/Fluorouracil; 65-71-4/Thymine; EC Dehydrogenase (NADP)

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