Document Detail

Possible physiological roles of acetone metabolism in humans.
MedLine Citation:
PMID:  10580530     Owner:  NLM     Status:  MEDLINE    
Recently, the metabolic routes for acetone metabolism have been described. Therefore, acetone cannot further be regarded as a waste product of metabolism. However, its physiological role in biochemical machinery is not clear. Here, an integrative model for the role of acetone metabolism is presented that orders the events occurring in acetonemia in sequence: (i) acetone participates in pH regulation; and (ii) acetone degradation in the liver both contributes to glucostatic function of the liver and provides C3 fragments to peripheral tissues as additional fuel. The model raises a novel approach to the study of the physiological role of acetone metabolism.
M P Kalapos
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medical hypotheses     Volume:  53     ISSN:  0306-9877     ISO Abbreviation:  Med. Hypotheses     Publication Date:  1999 Sep 
Date Detail:
Created Date:  1999-12-09     Completed Date:  1999-12-09     Revised Date:  2008-08-15    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  236-42     Citation Subset:  IM    
Theoretical Biology Research Group, Budapest, Hungary.
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MeSH Terms
Acetone / metabolism*
Liver / metabolism
Models, Biological*
Models, Chemical
Reg. No./Substance:

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