| Possible physiological roles of acetone metabolism in humans. | |
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MedLine Citation:
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PMID: 10580530 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recently, the metabolic routes for acetone metabolism have been described. Therefore, acetone cannot further be regarded as a waste product of metabolism. However, its physiological role in biochemical machinery is not clear. Here, an integrative model for the role of acetone metabolism is presented that orders the events occurring in acetonemia in sequence: (i) acetone participates in pH regulation; and (ii) acetone degradation in the liver both contributes to glucostatic function of the liver and provides C3 fragments to peripheral tissues as additional fuel. The model raises a novel approach to the study of the physiological role of acetone metabolism. |
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Authors:
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M P Kalapos |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Medical hypotheses Volume: 53 ISSN: 0306-9877 ISO Abbreviation: Med. Hypotheses Publication Date: 1999 Sep |
Date Detail:
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Created Date: 1999-12-09 Completed Date: 1999-12-09 Revised Date: 2008-08-15 |
Medline Journal Info:
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Nlm Unique ID: 7505668 Medline TA: Med Hypotheses Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 236-42 Citation Subset: IM |
Affiliation:
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Theoretical Biology Research Group, Budapest, Hungary. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetone
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metabolism* Humans Liver / metabolism Models, Biological* Models, Chemical |
| Chemical | |
Reg. No./Substance:
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67-64-1/Acetone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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