Document Detail


Possible patterns of epidermal melanocyte disappearance in non segmental vitiligo: A clinicopathological study.
MedLine Citation:
PMID:  24902987     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: The depigmentation of vitiligo results in a progressive and chronic melanocyte loss with sometimes rare melanocytes remaining in the epidermis or the hair follicle reservoirs. Destruction by immune infiltrates in close contact with melanocytes within microvesicles and/or detachment of melanocytes followed by their transepidermal elimination should be regarded as possible mechanisms of chronic loss of pigment cells.
OBJECTIVE: To assess the frequency of these two histological findings and finally to establish a direct correlation with clinical features.
METHODS: This was a prospective observational study that took place over one year. Each patient received a standardized evaluation that included daylight and Wood's light examinations, pictures, biopsies performed on the marginal area, and histological and immunohistological studies. A second examination to assess the activity of the lesions was performed one year after inclusion in the study. Clinical changes associated with microvesicles were compared with those associated with detached melanocytes from the basal layer.
RESULTS: This study included 50 patients. The histological findings were classified as inflammatory with isolated microvesicles (29 cases), non inflammatory with only detached melanocytes from the basal layer (12 cases) and mixed with coexistence of microvesicles and detached melanocytes (6 cases). Correlations were obtained between the histological findings and clinical features (aspect and activity of the lesions) and E-Cadherin expression.
CONCLUSION: Our data suggest the existence of two patterns of melanocyte disappearance in non segmental vitiligo. This article is protected by copyright. All rights reserved.
Authors:
L Benzekri; I Hmamouchi; Y Gauthier
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-6-5
Journal Detail:
Title:  The British journal of dermatology     Volume:  -     ISSN:  1365-2133     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-6-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
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