Document Detail


Possible pathophysiology of torsade de pointes evaluated by a realistic heart computer model.
MedLine Citation:
PMID:  3779739     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A realistic computer model that closely simulates the behaviour of the cardiac conduction system and myocardium in producing electrocardiographic records was used to evaluate some hypotheses of the pathophysiological mechanisms causing torsade de pointes tachycardia. Five different groups of experiments showed that pathological phenomena of different natures can either directly cause the usual pattern of torsade de pointes or contribute to its occurrence. The phenomena investigated were coincidence of two or more pathological foci with slightly changing periods of impulse generation; periodical disturbances of the conduction velocities of the main branches of the conduction system; a single pathological focus changing its position by slowly moving around the whole heart or around a local area of the myocardium; combination of a pathological ventricular tachycardia focus with a one way (ventriculoatrial) direct atrioventricular accessory pathway allowing atrioventricular re-entry; and different repolarisation periods of separate areas of heart muscle in the presence of a pathological ventricular focus with a fixed or oscillating rate of impulse generation. Future extended versions of the model could be used for testing other hypotheses of the origin of torsade de pointes, such as situations in which the intramuscle or local re-entry occurs.
Authors:
M Malik; A J Camm
Related Documents :
1279529 - Modification of late potentials by intracoronary ethanol infusion.
1138739 - Bidirectional tachycardia in a child. a study using his bundle electrography.
6691869 - Ventricular arrhythmias in idiopathic dilated cardiomyopathy.
6736479 - Limited role of intravenous propafenone hydrochloride in the treatment of sustained ven...
7404089 - Nifedipine for digitalis-induced arrhythmias.
15226969 - Exercise-induced right ventricular tachycardia and arrhythmogenic right ventricular dys...
10069309 - Emergency cardiopulmonary bypass for cardiac arrest refractory to pediatric advanced li...
25147029 - Randomized comparison of everolimus-eluting stents and sirolimus-eluting stents in pati...
12135129 - Shunt between the ventricular chamber and coronary arteries preserves left ventricular ...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cardiovascular research     Volume:  20     ISSN:  0008-6363     ISO Abbreviation:  Cardiovasc. Res.     Publication Date:  1986 Jun 
Date Detail:
Created Date:  1987-01-22     Completed Date:  1987-01-22     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0077427     Medline TA:  Cardiovasc Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  436-43     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Atrioventricular Node / physiopathology
Computer Simulation*
Electrocardiography
Heart Conduction System / physiopathology*
Heart Ventricles / physiopathology
Models, Cardiovascular*
Tachycardia / physiopathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Salvage of ischaemic myocardium by reperfusion: importance of collateral blood flow and myocardial o...
Next Document:  Evaluation of the QA interval as an index of cardiac contractility in anaesthetised dogs: responses ...